420321

KT5823

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

• 동의어(들): KT5823, PKG Inhibitor VII
• 실험식(Hill 표기법): C₂₉H₂₅N₃O₅
• CAS Number: 126643-37-6
• Molecular Weight: 495.53
• MDL number: MFCD09878278
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 1 mg/mL; DMF: soluble
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: [n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)CN(C7=O)C)cccc6)[C@@H]5O[C@]1([C@@](C5)(OC)C(=O)OC)C
• InChI: 1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
• InChI key: QTYMDECKVKSGSM-YMUMJAELSA-N

설명

일반 설명

Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM). Inhibits protein kinase C (K_i = 4.0 µM) and protein kinase A (K_i >10.0 µM) at higher concentrations.

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PKG

Product competes with ATP.

Reversible: yes

Target K_i: 234 nM against protein kinase G

경고

Toxicity: Standard Handling (A)

제조 메모

Further dilute with aqueous buffers just prior to use.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Grider, J.R. 1993. Am. J. Physiol.264, G334.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable