480402

NFAT Inhibitor

The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 동의어(들): NFAT Inhibitor, MAGPHPVIVITGPHEE
• 실험식(Hill 표기법): C₇₅H₁₁₈N₂₀O₂₂S
• CAS Number: 249537-73-3
• Molecular Weight: 1683.93
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• solubility: water: soluble
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A highly selective NFAT (Nuclear Factor of Activated T-cells) inhibitor that interferes with calcineurin-NFAT interaction without affecting calcineurin (Cat. No. 539568) phosphatase activity. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT.

A highly selective NFAT inhibitor that prevents NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells. Does not affect the expression of other cytokines requiring calcineurin, but not NFAT. Inhibits calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
NFAT (Nuclear Factor of Activated T-cells)

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

기타 정보

Noguchi, H., et al. 2004. Nat. Med.10, 305.
Kiani, A., et al. 2001. Blood98, 1480.
Aramburu, J., et al. 1999. Science285, 2129.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable