554718

REV-ERBα Antagonist, SR8278

The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.

• 동의어(들): REV-ERBα Antagonist, SR8278, SR8278SR 8278
• 실험식(Hill 표기법): C₁₈H₁₉NO₃S₂
• CAS Number: 101910-24-1
• Molecular Weight: 361.48
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: >95% (HPLC)
• 형태: gum; solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white to yellow-brown
• solubility: DMSO: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC₅₀ = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC₅₀ = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.

포장

Packaged under inert gas

경고

Toxicity: Regulatory Review (Z)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

기타 정보

Kojetin, D., et al. 2010, Chem Bio in press

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable