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Merck
모든 사진(1)

주요 문서

658411

Sigma-Aldrich

AG490

InSolution, ≥98%, inhibitor of EGFR kinase autophosphorylation

동의어(들):

InSolution AG490, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C17H14N2O3
Molecular Weight:
294.30
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

형태

liquid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
desiccated (hygroscopic)
protect from light

배송 상태

wet ice

저장 온도

−70°C

일반 설명

Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.

재구성

Following initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.

기타 정보

Jaleel, M., et al. 2004. Biochemistry43, 8247.
Eriksen, K.W., et al. 2001. Leukemia15, 787.
Kirken, R.A., et al. 1999. Leukoc. Biol.65, 891.
Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
Meydan, N., et al. 1996. Nature 379, 645.
Gazit, A., et al. 1991. J. Med. Chem.34, 1896.
Levitzki, A. 1990. Biochem. Pharmacol.40, 913.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Flash Point (°C)

87 °C - closed cup - (Dimethylsulfoxide)

시험 성적서(COA)

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