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Merck
모든 사진(1)

Key Documents

ABE571

Sigma-Aldrich

Anti-SOX9 Antibody

from rabbit, purified by affinity chromatography

동의어(들):

Transcription factor SOX-9

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

정제법

affinity chromatography

종 반응성

mouse

종 반응성(상동성에 의해 예측)

rat (based on 100% sequence homology), human (based on 100% sequence homology)

기술

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... SOX9(6662)

일반 설명

Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

면역원

Linear peptide corresponding to the C-terminus of human SOX9.

애플리케이션

Anti-SOX9 Antibody is a highly specific rabbit polyclonal antibody, that targets SOX9 & has been tested in western blotting, IHC & Immunofluorescence.
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected SOX9 in K14 mouse backskin tissue (Nowak, J. A., et al. (2008). Cell Stem Cell. 3(1):33-43.).

Immunofluorescence Analysis: A representative lot from an independent laboratory detected SOX9 in mouse Label Retaining cells, and developing epithelial skin and hair follicle cells (Nowak, J. A., et al. (2008). Cell Stem Cell. 3(1):33-43.).
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

품질

Evaluated by Western Blotting in NIH/3T3 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected SOX9 in 10 µg of NIH/3T3 cell lysate.

표적 설명

~63 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

물리적 형태

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Sean Richards et al.
The American journal of pathology, 190(3), 602-613 (2020-03-03)
Casitas B-lineage lymphoma (c-Cbl) is a recently identified ubiquitin ligase of nuclear β-catenin and a suppressor of colorectal cancer (CRC) growth in cell culture and mouse tumor xenografts. We hypothesized that reduction in c-Cbl in colonic epithelium is likely to
Yu-Chi Shen et al.
Nature communications, 12(1), 3876-3876 (2021-06-25)
Testicular development and function rely on interactions between somatic cells and the germline, but similar to other organs, regenerative capacity declines in aging and disease. Whether the adult testis maintains a reserve progenitor population remains uncertain. Here, we characterize a
Jack W Hickmott et al.
Molecular therapy. Methods & clinical development, 3, 16051-16051 (2016-08-25)
Current gene therapies predominantly use small, strong, and readily available ubiquitous promoters. However, as the field matures, the availability of small, cell-specific promoters would be greatly beneficial. Here we design seven small promoters from the human paired box 6 (PAX6)
Shuyu Guo et al.
Cell death and differentiation, 25(11), 1996-2009 (2018-03-11)
The role of GATA-binding protein 4 (GATA4) in neural crest cells (NCCs) is poorly defined. Here we showed that mouse NCCs lacking GATA4 exhibited developmental defects in craniofacial bone, teeth, and heart. The defects likely occurred due to decreased cell
Parash Parajuli et al.
Life science alliance, 3(6) (2020-05-07)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that remains incurable because of late diagnosis, which renders any therapeutic intervention challenging. Most PDAC patients develop de novo diabetes, which exacerbates their morbidity and mortality. How PDAC triggers diabetes is still

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