추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
정제법
affinity chromatography
종 반응성
human, mouse
기술
immunohistochemistry: suitable (tissue)
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... SOX11(6664)
일반 설명
SRY box-containing 11 (Sox11) is a neural transcription factor belonging to the DNA-binding high-mobility group (HMG) box protein super family. It is highly expressed during embryonic development and regulates genes involved in neurite growth and survival. Sox11 plays an important role in the formation of sensory neurons and organogenesis. Sox11-deficient mice show defects in multiple organs including the lung, heart, and pancreas. Sox11 also plays a critical role as a tumor suppressor. Epigenetic suppression of the Sox11 gene, primarily through promoter hypermethylation, contributes to various forms of neoplasms. In adults, Sox11 may be involved in the regeneration of neurons after nerve injury by inducing the expression of the small proline rich protein 1a gene (Sprr1a).
면역원
KLH-conjugated linear peptide corresponding to human Sox-11.
애플리케이션
Anti-Sox11 Antibody detects level of Sox11 & has been published & validated for use in 0.
Immunohistochemistry: A 1:1,000 dilution from a representative lot detected Sox-11 in normal mouse hippocampus and cerebellum tissues.
Western Blot Analysis: A representative lot detecte Sox-11 in human brain tissue lysate.
Western Blot Analysis: A representative lot detecte Sox-11 in human brain tissue lysate.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
품질
Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 0.5 mg/mL of this antibody detected Sox-11 in 10 mg of mouse brain tissue lysate.
Western Blot Analysis: 0.5 mg/mL of this antibody detected Sox-11 in 10 mg of mouse brain tissue lysate.
표적 설명
~57 kDa observed
물리적 형태
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
분석 메모
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yuyan Cheng et al.
Nature communications, 13(1), 4418-4418 (2022-07-30)
The inability of neurons to regenerate long axons within the CNS is a major impediment to improving outcome after spinal cord injury, stroke, and other CNS insults. Recent advances have uncovered an intrinsic program that involves coordinate regulation by multiple
Elena Spina et al.
Nature communications, 13(1), 1421-1421 (2022-03-19)
Gpr125 is an orphan G-protein coupled receptor, with homology to cell adhesion and axonal guidance factors, that is implicated in planar polarity and control of cell movements. By lineage tracing we demonstrate that Gpr125 is a highly specific marker of
Rotem Ben-Tov Perry et al.
Cell reports, 42(10), 113168-113168 (2023-09-24)
Long noncoding RNAs (lncRNAs) are expressed in many brain circuits and types of neurons; nevertheless, their functional significance for normal brain functions remains elusive. Here, we study the functions in the central nervous system of Silc1, an lncRNA we have
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