ABN200

Anti-C-X-C chemokine receptor type 5 (CXCR5) Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): C-X-C chemokine receptor type 5, CXC-R5, CXCR-5, Burkitt lymphoma receptor 1, Monocyte-derived receptor 15, MDR-15, CD185
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse, human
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI 수납 번호: NP_001707
• UniProt 수납 번호: P32302
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CXCR5(643)

설명

일반 설명

C-X-C chemokine receptor type 5 (CXCR5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15) is a G-protein coupled cytokine receptor that binds selectively to the CXCL13 (B lymphocyte chemoattractant) ligand, and mediates the development and function of the immune system. It is expressed in mature B cells, and facilitates the migration of B cells into follicles of the splenic white pulp, and enables deposition of antigen on follicular dendritic cells. It is also involved in the development of lymph nodes and Peyer’s patches. Previous studies have reported that the expression of CXCR5 increases in rheumatoid arthritis.

특이성

This antibody recognizes the cytoplasmic domain of C-X-C chemokine receptor type 5 (CXCR5).

면역원

Epitope: Cytoplasmic domain

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human C-X-C chemokine receptor type 5 (CXCR5).

애플리케이션

Anti-C-X-C chemokine receptor type 5 (CXCR5) Antibody is an antibody against C-X-C chemokine receptor type 5 (CXCR5) for use in Western Blotting, IHC(P).

Immunohistochemistry Analysis: A 1:1,000 dilution from representative lot detected C-X-C chemokine receptor type 5 (CXCR5) in mouse frontal cortex neurons and mouse spleen lymphocytes.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

품질

Evaluated by Western Blot in SH-SY5Y cell lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected C-X-C chemokine receptor type 5 (CXCR5) in 10 µg of SH-SY5Y cell lysate.

표적 설명

~51 / 38 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing with molecular weights ~42 and ~37 kDa The calculated molecular weight of this protein is 42 kDa, but can be observed at ~51 kDa due to high glycosylation.

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
SH-SY5Y cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable