MAB10005

Anti-ABCA1 Antibody, clone AB.H10

clone AB.H10, Chemicon^®, from mouse

• 동의어(들): ATP-binding cassette transporter 1, ABC-1, Cholesterol efflux regulatory protein
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: AB.H10, monoclonal
• 종 반응성: human, chicken, mouse
• 제조업체/상표: Chemicon^®
• 기술: ELISA: suitable; immunohistochemistry: suitable (paraffin); immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgG1
• NCBI 수납 번호: NM_005502.2
• UniProt 수납 번호: O95477
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ABCA1(19)

설명

일반 설명

Mutations in the ABCA1 gene are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

특이성

Recognize specifically ABCA1 from human, mouse, and chicken.

면역원

Recombinant fragment, corresponding to amino acids 1800-2260 of Human ABCA1.

애플리케이션

ELISA
Immunohistochemistry (Paraffin): 5 μg/mL. Perform heat mediated antigen retrieval in sodium citrate buffer (pH 6), before commencing with IHC staining protocol. Amplification with biotin-streptavidin may be required.
Immunoprecipitation
Western Blot: 1 μg/mL. Predicted molecular weight: 254 kDa.

Optimal working dilutions must be determined by end user.

Research Category
Metabolism

Research Sub Category
Lipid Metabolism & Weight Regulation

This Anti-ABCA1 Antibody, clone AB.H10 is validated for use in ELISA, IP, WB, IH(P) for the detection of ABCA1.

물리적 형태

Format: Purified

Presented as a liquid in PBS, pH 7.4 with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stable at 4°C for 3 months.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable