추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
7C6.D10, monoclonal
종 반응성
human
제조업체/상표
Chemicon®
기술
western blot: suitable
동형
IgG1κ
GenBank 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... SCRIB(23513)
일반 설명
Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).
특이성
Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.
면역원
Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble
애플리케이션
Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Western blot: 0.2 µg (1:2000)
Research Sub Category
Tumor Markers
Cytoskeleton
Tumor Markers
Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.
품질
Routinely evaluated by Western blot on HeLa cell lysates.
표적 설명
220 kDa
물리적 형태
Format: Purified
Purified in PBS containing with 0.05% NaN3.
저장 및 안정성
Maintain at 2-8°C for up to 1 year after date of receipt.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
I F Bambang et al.
Oncogene, 32(10), 1240-1251 (2012-05-01)
The epithelial-mesenchymal transition (EMT) correlates with disruption of cell-cell adhesion, loss of cell polarity and development of epithelial cell malignancy. Identifying novel molecules that inhibit EMT has profound potential for developing mechanism-based therapeutics. We previously demonstrated that the endoplasmic reticulum
Sang Joon Won et al.
ACS chemical biology, 13(6), 1560-1568 (2018-05-08)
S-palmitoylation is required for membrane anchoring, proper trafficking, and the normal function of hundreds of integral and peripheral membrane proteins. Previous bioorthogonal pulse-chase proteomics analyses identified Ras family GTPases, polarity proteins, and G proteins as rapidly cycling S-palmitoylated proteins sensitive
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