MAB2056
Anti-Integrin α3 Antibody, clone ASC-1
clone ASC-1, Chemicon®, from mouse
동의어(들):
CD49c
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모든 사진(1)
About This Item
UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
클론:
ASC-1, monoclonal
application:
FACS
IHC
IP
IHC
IP
종 반응성:
human
기술:
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
citations:
8
추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
ASC-1, monoclonal
종 반응성
human
제조업체/상표
Chemicon®
기술
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
동형
IgG1κ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... ITGA3(3675)
관련 카테고리
특이성
Human alpha3 integrin (CD49c)
면역원
Human squamous cell carcinoma cells (SCC9)
애플리케이션
Anti-Integrin α3 Antibody, clone ASC-1 detects level of Integrin α3 & has been published & validated for use in FC, IP, IH.
Inhibition of cell attachment: inhibits SCC9 cell adhesion to human and
EHS laminin, and laminin GD-2 peptide. Potentiates inhibition of SKOV-3 cell adhesion to EHS laminin by anti-integrin alpha 5 antibody GoH3. Does not inhibit cell adhesion to fibronectin or collagen type IV.
Immunohistochemistry: on acetone-fixed frozen human epithelial tissues including tongue, foreskin and ovary. Not for use on formalin-fixed tissue.
Flow cytometry: stains human squamous cell carcinoma (SCC9), ovarian carcinoma (SKOV-3) and umbilical vein endothelial cells (HUVEC).
Immunoprecipitation: precipitates PAGE bands of 130kDa (reduced) or 116kDa and 135kDa (non-reduced) from surface-biotinylated SCC9 or SKOV-3 cells.
Working dilutions must be determined by end user.
EHS laminin, and laminin GD-2 peptide. Potentiates inhibition of SKOV-3 cell adhesion to EHS laminin by anti-integrin alpha 5 antibody GoH3. Does not inhibit cell adhesion to fibronectin or collagen type IV.
Immunohistochemistry: on acetone-fixed frozen human epithelial tissues including tongue, foreskin and ovary. Not for use on formalin-fixed tissue.
Flow cytometry: stains human squamous cell carcinoma (SCC9), ovarian carcinoma (SKOV-3) and umbilical vein endothelial cells (HUVEC).
Immunoprecipitation: precipitates PAGE bands of 130kDa (reduced) or 116kDa and 135kDa (non-reduced) from surface-biotinylated SCC9 or SKOV-3 cells.
Working dilutions must be determined by end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
결합
Replaces: CBL462B
물리적 형태
Format: Purified
Liquid in 0.02M phosphate buffer, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
저장 및 안정성
Maintain at 2-8°C in undiluted aliquots for up to 12 months.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Paul Day et al.
International journal of oncology, 39(4), 863-871 (2011-07-02)
Integrins, a family of heterodimeric receptors for cell adhesion to the extracellular matrix (ECM), play key roles in cell migration, cancer progression and metastasis. As transmembrane proteins, integrins are transported in vesicles and delivered to the cell surface by vesicular
Edith Hintermann et al.
The Journal of cell biology, 153(3), 465-478 (2001-05-02)
Keratinocytes and other epithelial cells express two receptors for the basement membrane (BM) extracellular matrix component laminin-5 (Ln-5), integrins alpha 3 beta 1 and alpha 6 beta 4. While alpha 3 beta 1 mediates adhesion, spreading, and migration (Kreidberg, J.A.
Julia K L Woodward et al.
Investigative ophthalmology & visual science, 46(10), 3473-3477 (2005-09-28)
TGFbeta has been shown to have a regulatory effect on uveal melanoma invasion, but it is not known which processes are specifically influenced. The purpose of this study was to analyze the effect of TGFbeta stimulation on the adhesive interactions
M Shang et al.
The Journal of biological chemistry, 276(35), 33045-33053 (2001-06-08)
Laminins are a family of extracellular matrix glycoproteins involved in cell adhesion and migration. A major obstacle to understanding their structure-function relationships is the lack of small laminin domains capable of replicating integrin-binding, cell-adhesive, and migratory functions of the intact
Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc.
Chen, J; Jing, L; Gilchrist, CL; Richardson, WJ; Fitch, RD; Setton, LA
Connective tissue research null
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