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Merck
모든 사진(1)

문서

MAB8705

Sigma-Aldrich

Anti-Dengue Virus Complex Antibody, clone D3-2H2-9-21

clone D3-2H2-9-21, Chemicon®, from mouse

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

클론

D3-2H2-9-21, monoclonal

종 반응성

human

제조업체/상표

Chemicon®

기술

immunocytochemistry: suitable
immunofluorescence: suitable

동형

IgG2a

배송 상태

wet ice

일반 설명

Dengue fever is an acute, mosquito-transmitted viral disease characterized by fever, headache, arthralgia (severe retro-orbital pain), myalgia, rash, nausea, and vomiting. Infections are caused by any of the four closely related, but antigenically distinct virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). Infection with one of these serotypes does not provide cross-protective immunity, so persons living in a dengue-endemic area can have four dengue infections during their lifetimes. Dengue is primarily an urban disease of the tropics, and the viruses that cause it are maintained in a cycle that involves humans and Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans. Although most dengue infections result in relatively mild illness, some can produce Dengue Hemorrhagic Fever (DHF) or dengue shock syndrome, with children being particularly at risk. Although epidemic outbreaks have been reported since 1779, the incidence has been increasing, with global, multiple serotype pandemics intensifying within the last 15 years. There is no specific antiviral therapy for dengue, but for both classical dengue and dengue hemorrhagic fever, symptomatic and supportive measures are effective. Important risk factors for DHF include the strain and serotype of the virus involved, as well as the age, immune status, and genetic predisposition of the patient.

특이성

Reacts with all members of the Dengue complex.

면역원

Dengue type 4 virus antigens.

애플리케이션

Detect Dengue Virus Complex using this Anti-Dengue Virus Complex Antibody, clone D3-2H2-9-21 validated for use in IC & IF.
Immunofluorescence.

Immunocytochemistry on acetone fixed material.

Suggested working dilution: 1:50-400.

Final working dilutions must be determined by end user.
Research Category
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral

물리적 형태

Format: Purified
Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Protein A purified

저장 및 안정성

Maintain for 6 months at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

분석 메모

Control
Dengue positive patient sample

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention.
Goncalvez, AP; Engle, RE; St Claire, M; Purcell, RH; Lai, CJ
Proceedings of the National Academy of Sciences of the USA null
Albin Fontaine et al.
Scientific reports, 6, 24885-24885 (2016-04-28)
Successful transmission of a vector-borne pathogen relies on a complex life cycle in the arthropod vector that requires initial infection of the digestive tract followed by systemic viral dissemination. The time interval between acquisition and subsequent transmission of the pathogen
Nattapol Attatippaholkun et al.
Scientific reports, 8(1), 2688-2688 (2018-02-11)
Since the hemorrhage in severe dengue seems to be primarily related to the defect of the platelet, the possibility that dengue virus (DENV) is selectively tropic for one of its surface receptors was investigated. Flow cytometric data of DENV-infected megakaryocytic
Heart and skeletal muscle are targets of dengue virus infection.
Doris Martha Salgado,Jose Miguel Eltit,Keith Mansfield,Cesar Panqueba,Dolly Castro et al.
The Pediatric Infectious Disease Journal null
Modulation of ?-enolase post-translational modifications by dengue virus: increased secretion of the basic isoforms in infected hepatic cells.
Higa, LM; Curi, BM; Aguiar, RS; Cardoso, CC; De Lorenzi, AG; Sena, SL; Zingali, RB; Da Poian, AT
Testing null

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