추천 제품
Grade
analytical standard
Quality Level
분석
≥98% (HPLC)
기술
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
응용 분야
forensics and toxicology
pharmaceutical (small molecule)
veterinary
형식
neat
저장 온도
−20°C
SMILES string
NC(=O)N1c2ccccc2C3OC3c4ccccc14
InChI
1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)
InChI key
ZRWWEEVEIOGMMT-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Carbamazepine 10,11-epoxide is a metabolite of the drug carbamazepine.
애플리케이션
Carbamazepine 10,11-epoxide may be used as a test material in the quantification of histone deacetylases(HDAC) inhibition using fluorescent HDAC activity assay.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
생화학적/생리학적 작용
First metabolite of carbamazepine
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Gwendolyn A McMillin et al.
American journal of clinical pathology, 133(5), 728-736 (2010-04-17)
Carbamazepine is metabolized to an active metabolite known as carbamazepine-10,11-epoxide, or simply the "epoxide" metabolite. The presence of this metabolite can have clinically significant implications in therapeutic drug monitoring of carbamazepine, but accurate quantification of the epoxide metabolite is currently
Hai-Zhi Bu et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(12), 1920-1924 (2005-10-06)
The clinical use of carbamazepine (CBZ), an anticonvulsant, is associated with a variety of idiosyncratic adverse reactions that are likely related to the formation of chemically reactive metabolites. CBZ-10,11-epoxide (CBZE), a pharmacologically active metabolite of CBZ, is so stable in
W Qiu et al.
Phytotherapy research : PTR, 23(11), 1553-1558 (2009-04-17)
The in vivo effects of berberine (BBR), the widely used bioactive herbal ingredient from many traditional Chinese medicinal herbs, on the pharmacokinetics of carbamazepine (CBZ, a substrate of CYP3A) and its metabolite carbamazepine 10,11-epoxide (ECBZ), digoxin (DIG, a substrate of
Terumitsu Yoshida et al.
Journal of pharmaceutical and biomedical analysis, 41(4), 1386-1390 (2006-04-07)
This study developed a simple method for the simultaneous determination of zonisamide (ZNS), carbamazepine (CBZ) and its active metabolite, carbamazepine-10,11-epoxide (CBZE) in infant serum using reversed-phase high-performance liquid chromatograph (HPLC). The method involves a single-step protein precipitation procedure that uses
Kyoung-Ah Kim et al.
European journal of clinical pharmacology, 61(4), 275-280 (2005-05-26)
Carbamazepine (CBZ) undergoes biotransformation by CYP3A4 and CYP2C8, and glucuronide conjugation. There has been no clear demonstration to reveal the role of glucuronidation in the disposition of CBZ. We evaluated the effect of probenecid, a UDP-glucuronosyltransferase inhibitor, on the pharmacokinetics
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