H3393

Heparin sodium salt from porcine intestinal mucosa

Grade I-A, ≥180 USP units/mg

• 동의어(들): Sodium heparin
• CAS Number: 9041-08-1
• MDL number: MFCD00081689
• UNSPSC 코드: 12352201
• NACRES: NA.21

속성

• 생물학적 소스: Porcine intestinal mucosa
• Quality Level: 200
• 유형: Grade I-A
• 양식: powder
• 특이 활성도: ≥180 USP units/mg
• 색상: beige
• 유용한 pH 범위: 5.0 - 7.5
• solubility: H₂O: 50 mg/mL, clear, colorless to faintly yellow
• 응용 분야: clinical research; diagnostic assay manufacturing; life science and biopharma
• 저장 온도: room temp
• SMILES string: [Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O
• InChI key: JRTRSJGZMRQDHI-UHFFFAOYSA-N

설명

일반 설명

Heparin is a glycosaminoglycan (GAG) belonging to the mucopolysaccharides family, known for its potent anticoagulant properties. This extensively sulfated polysaccharide consists of D-glucosamine and hexuronic acid linked via glycosidic linkages. It finds wide application in biochemical research and cell culture studies.

애플리케이션

Heparin sodium salt from porcine intestinal mucosa has been supplemented in the medium prepared for insemination of oocytes with spermatozoa. Heparin sodium salt from porcine intestinal mucosa has been used:

• to check the effect of heparin on FGF21 (fibroblast growth factor 21) signaling.
• in immunostaining of mice brain sections
• to quantify white blood cells and red blood cells in Sparus aurata blood samples
• in anticoagulation and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) inhibition assay

생화학적/생리학적 작용

Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.

Heparin is synthesized in mast cells and mediators such as histamine and is associated with allergy and inflammatory activity. Heparin shows therapeutic effects against venous thrombosis and pulmonary embolism, helps in preventing re-thrombosis post thrombolysis, and manages arterial thrombosis in patients who suffer from acute myocardial infarction. Heparin shows anti-inflammatory action in many inflammatory conditions such as burns, bronchial asthma, and ulcerative colitis.

기타 정보

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Heparin solutions should not be autoclaved as additional crosslinking of the sugars may occur at high temperatures. It should not be frozen as well.

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

추천 제품

Heparin for diagnostic manufacturing is available as product number SRE0027

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)