RDD039

Imidazole

for molecular biology, ≥99% (titration), free-flowing, Redi-Dri^™

• 동의어(들): 1, 3-diazole, 1,3-Diaza-2,4-cyclopentadiene, Glyoxaline
• 실험식(Hill 표기법): C₃H₄N₂
• CAS Number: 288-32-4
• Molecular Weight: 68.08
• Beilstein: 103853
• MDL number: MFCD00005183
• UNSPSC 코드: 12352200
• NACRES: NA.21

속성

• Grade: for molecular biology
• Quality Level: 100
• vapor pressure: <1 mmHg ( 20 °C)
• 제품 라인: Redi-Dri^™
• 분석: ≥99% (titration)
• 형태: crystalline powder
• 품질: free-flowing
• pH: 6.2-7.8 (25 °C)
• pKa(25 °C): 6.95
• bp: 256 °C (lit.)
• mp: 88-91 °C (lit.)
• 응용 분야: diagnostic assay manufacturing
• 외래 활성: DNase, RNase and protease, none detected
• SMILES string: c1c[nH]cn1
• InChI: 1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
• InChI key: RAXXELZNTBOGNW-UHFFFAOYSA-N

설명

일반 설명

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.

애플리케이션

Imidazole has been used

• in the lysis, wash, and elution buffer for the purification of histidine tagged proteins
• in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
• as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells

Excellent for buffers in the range of pH 6.2-7.8

생화학적/생리학적 작용

Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).

특징 및 장점

• Qualified for molecular biology applications, DNase, Rnase, and protease free
• Redi-Dri^™ packaging controls moisture, eliminating clumps
• Crystalline powder remains free-flowing and much easier to use
• Safer to handle and weigh out for routine use in lab
• Less waste, loss of drying, while maintaining high quality

기타 정보

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법적 정보

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H314,H360D
• 예방조치 성명서: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point (°F): 293.0 °F - closed cup
• Flash Point (°C): 145 °C - closed cup