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Merck
모든 사진(2)

주요 문서

22244

Sigma-Aldrich

Ceramide from bovine spinal cord

≥98.0% (TLC)

동의어(들):

Bovine Spinal Cord Ceramide

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About This Item

MDL number:
UNSPSC 코드:
12352211
NACRES:
NA.25

생물학적 소스

bovine spinal cord

Quality Level

분석

≥98.0% (TLC)

형태

solid

불순물

α-hydroxy fatty acids

solubility

chloroform/methanol (99:1): 20 mg/mL, clear, colorless

지질 유형

sphingolipids

배송 상태

wet ice

저장 온도

−20°C

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Ceramide is used to investigate effects on programmed cell death (apoptosis) and insulin signaling.

생화학적/생리학적 작용

Ceramide is a minor component of cell membranes. Activates atypical protein kinase C (e.g., PKCzeta) .

제조 메모

from cerebrosides by a modification of the procedure by H.E. Carter et al., J. Lipid Res. 2, 228 (1961)

기타 정보

Sales restrictions may apply

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

Darren J Powell et al.
Molecular and cellular biology, 23(21), 7794-7808 (2003-10-16)
Ceramide is generated in response to numerous stress-inducing stimuli and has been implicated in the regulation of diverse cellular responses, including cell death, differentiation, and insulin sensitivity. Recent evidence indicates that ceramide may regulate these responses by inhibiting the stimulus-mediated
Huijing Yin et al.
Nature communications, 12(1), 4230-4230 (2021-07-11)
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The EMBO journal, 36(22), 3356-3371 (2017-10-12)
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques.

문서

Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.

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