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Merck
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주요 문서

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28605

Sigma-Aldrich

3-Cyanoumbelliferone

BioReagent, suitable for fluorescence, ≥98.0% (TLC)

동의어(들):

3-Cyano-7-hydroxycoumarin

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About This Item

실험식(Hill 표기법):
C10H5NO3
CAS Number:
19088-73-4
Molecular Weight:
187.15
Beilstein:
153271
MDL number:
MFCD00037480
UNSPSC 코드:
12352108
PubChem Substance ID:
57648313
NACRES:
NA.32

제품 라인

BioReagent

Quality Level

100

분석

≥98.0% (TLC)

형태

powder

mp

≥250 °C (lit.)

solubility

DMF: soluble
alcohols: soluble

형광

λex 408 nm; λem 450 nm in methanol

적합성

suitable for fluorescence

SMILES string

Oc1ccc2C=C(C#N)C(=O)Oc2c1

InChI

1S/C10H5NO3/c11-5-7-3-6-1-2-8(12)4-9(6)14-10(7)13/h1-4,12H

InChI key

IJQYTHQDUDCJEQ-UHFFFAOYSA-N

유전자 정보

human ... MIF(4282)

애플리케이션

3-Cyano-7-hydroxycoumarin is closely related to 3-cyano-7-ethoxycoumarin which is used as a fluorometric substrate and inhibitor for cytochrome P-450 enzymes and cytochrome P-450-dependent mixed function oxidases. 3-Cyano-7-hydroxycoumarin may be useful to study the kinetics and substrate specificity of cytochrome P-450s.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302 + H312 + H332,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Jay J Agarwal et al.
PloS one, 8(5), e63028-e63028 (2013-05-15)
TRAM-34, a clotrimazole analog characterized as a potent and selective inhibitor of intermediate-conductance, calcium-activated K(+) (IKCa) channels, has been used extensively in vitro and in vivo to study the biological roles of these channels. The major advantage of TRAM-34 over
Joonyoung F Joung et al.
Physical chemistry chemical physics : PCCP, 19(37), 25509-25517 (2017-09-14)
Proton dissociation (PD) reactions of weak acids and proton transfer (PT) processes in aqueous solutions are strongly influenced by ions. However, a detailed molecular picture that describes how ions affect the rates of PD and PT processes is still missing.
Corinna Krempl et al.
Insect biochemistry and molecular biology, 78, 69-77 (2016-10-18)
Gossypol is a polyphenolic secondary metabolite produced by cotton plants, which is toxic to many organisms. Gossypol's aldehyde groups are especially reactive, forming Schiff bases with amino acids of proteins and cross-linking them, inhibiting enzyme activities and contributing to toxicity.
Samuel Koenig et al.
Aquatic toxicology (Amsterdam, Netherlands), 108, 11-17 (2011-11-19)
Variations in cytochrome P450 enzyme (CYPs) distribution and function between animal groups could result in differential metabolism and elimination kinetics for certain contaminants. Although a number of studies have suggested that differences in polychlorobiphenyl (PCB) accumulation profiles between crustacea and
I N White
Analytical biochemistry, 172(2), 304-310 (1988-08-01)
A direct fluorometric procedure for the continuous determination of cytochrome P-450-dependent mixed function oxidases, using 3-cyano-7-ethoxycoumarin substrate, is described. The reaction product, 3-cyano-7-hydroxycoumarin, is fluorescent at neutral pH values (excitation and emission wavelength maxima: 408 and 450 nm, respectively). Using
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