A0638

Adipic acid dihydrazide

≥98% (titration)

• 동의어(들): Hexanedihydrazide
• Linear Formula: NH₂NHCO(CH₂)₄CONHNH₂
• CAS Number: 1071-93-8
• Molecular Weight: 174.20
• Beilstein: 973863
• EC Number: 213-999-5
• MDL number: MFCD00007614
• UNSPSC 코드: 12352127
• PubChem Substance ID: 24890442
• NACRES: NA.25

속성

• Quality Level: 300
• 분석: ≥98% (titration)
• 형태: powder
• 반응 적합성: reagent type: cross-linking reagent
• mp: 180-182 °C (lit.)
• solubility: H₂O: 100 mg/mL
• 저장 온도: −20°C
• SMILES string: NNC(=O)CCCCC(=O)NN
• InChI: 1S/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12)
• InChI key: IBVAQQYNSHJXBV-UHFFFAOYSA-N

설명

일반 설명

Adipic acid dihydrazide is a homobifunctional cross-linking reagent that is specific for aldehydes. This results in relatively stable hydrazone linkages. Adipic acid dihydrazide is generally used in the linking of glycoproteins, like antibodies, in a site-specific fashion following periodate oxidation. Oxidation and coupling may be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.

애플리케이션

Adipic acid dihydrazide has been used:

• in the preparation of reactive premix to synthesize the porous biomaterial
• for the crosslinking of methacrylated chondroitin sulfate (MA-CS) coating using carbodiimide-based chemistry for the production and characterization of methacrylated chondroitin sulfate magnetic nanoparticles (MA-CS MNPs)
• for the covalent labeling of rhamnolipids, pyochelin, and vancomycin with Abberior STARNHS ester dye

생화학적/생리학적 작용

Adipic acid dihydrazide (ADH) is a low molecular weight compound that comprises a hydrazide group at each end. This leads to the supply of extra adsorption sites for heavy metals that maintain or elevate the adsorption capacities of the cross-linked adsorbents. ADH is used as a crosslinker in various fields, like making mechanical latexes films and injectable oxidized hyaluronic acid hydrogel.

기타 정보

Note that the hydrazone bond may be stabilized by selective reduction using, for example, sodium cyanoborohydride.

안전성 정보

• 픽토그램: GHS09
• 유해 및 위험 성명서: H411
• 예방조치 성명서: P273 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): 302.0 °F - closed cup
• Flash Point (°C): 150 °C - closed cup
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)