A0752

Adenosine 5′-diphosphoribose sodium salt

≥93%

• 동의어(들): ADPR, ADP-Ribose
• 실험식(Hill 표기법): C₁₅H₂₃N₅O₁₄P₂
• CAS Number: 68414-18-6
• Molecular Weight: 559.32
• MDL number: MFCD00136017
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24890449
• NACRES: NA.51

속성

• 생물학적 소스: yeast (candida utilis)
• Quality Level: 200
• 분석: ≥93%
• 양식: powder
• 저장 온도: −20°C
• SMILES string: [Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O
• InChI: 1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;
• InChI key: NWPVXDZLQTURKI-UHFFFAOYSA-N

설명

애플리케이션

5′-Deoxy-5′-(methylthio)adenosine has been used:

• to give a range of nicotinamide adenine dinucleotide (NADH)
• oxidation rates for the respiratory complex (CI/CIII/CIV)
• CI/alternative(AOX) pathway
• to measure poly(ADP-ribose) glycohydrolaseactivity
• poly(ADP-ribose) (PAR) binding competition assay
• oxidase (AOX) pathway
• to measure poly(ADP-ribose) glycohydrolase activity
• poly(ADP-ribose) (PAR) binding competition assay

생화학적/생리학적 작용

Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling. ADP-Ribose initiates the transient receptor potential subfamily melastatin, type2 (TRPM2), a Na⁺, Ca2⁺, and K⁺ cation channel.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves