추천 제품
생물학적 소스
goat
Quality Level
재조합
expressed in goat
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
lyophilized powder
종 반응성
human
기술
ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1 μg/mL
UniProt 수납 번호
응용 분야
research pathology
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... INHBA(3624)
일반 설명
Activin A protein belongs to the transforming growth factor-β (TGF-β) superfamily. This protein is a homodimer of two βA subunits. The INHBA gene is located on the human chromosome at 7p14.1.
면역원
recombinant human activin A expressed in CHO cells.
애플리케이션
Anti-Activin A antibody can be used for immunohistochemistry (5-15 μg/mL), western blot (0.1 μg/mL) and neutralization assays.
Anti-Activin A antibody produced in goat has been used in immunohistochemical staining.
생화학적/생리학적 작용
Activin A protein is involved in regulating developmental genes such as cell cycle regulators like p21, p15, paired box protein (Pax-6) and hormones like follicle-stimulating hormone (FSH). This protein also regulates its antagonist like follistatin and mothers against decapentaplegic homolog 7 (SMAD7). Activin A protein binds to the type 1 receptor activin receptor type 1B (ActR1B) and type 2 receptor activin receptor 2A and 2B (ActRIIA and ActRIIB). Activin A gene is highly expressed in esophageal carcinoma, lung adenocarcinoma, and malignant pleural mesothelioma (MPM). This gene expression is decreased during breast cancer, neuroblastoma, and hepatocellular carcinoma (HCC). Activins bind to the type II Activin receptor triggering phosphorylation of type I Activin receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis. Activin acts as a tumor suppressor by reducing cell proliferation in cancer cells.
물리적 형태
Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Cornelia Schuster et al.
The journal of pathology. Clinical research, 5(1), 53-62 (2018-09-19)
The incidence of malignant melanoma is rising worldwide and survival for metastatic disease is still poor. Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment for this patient group. In this study, we investigated
Nobuya Daitoku et al.
Oncology reports, 47(6) (2022-04-22)
Activin A is a member of the transforming growth factor‑β superfamily of cytokines and displays various pathophysiological activities, including regulation of muscle catabolism and atrophy. Activin A expression is upregulated in several human cancer types and in certain pathologies, its expression is
Alexander Ries et al.
Expert opinion on therapeutic targets, 24(10), 985-996 (2020-07-24)
Activin A is involved in the regulation of a surprisingly broad number of processes that are relevant for cancer development and treatment; it is implicated in cell autonomous functions and multiple regulatory functions in the tumor microenvironment. This article summarizes
Kun-Ming Rau et al.
Anticancer research, 31(5), 1713-1720 (2011-05-28)
Molecular mechanisms responsible for carcinogenesis in upper urinary tract urothelial carcinoma (UUTUC) are not yet clear. This study aimed to examine and correlate the subcellular localization of activin A, maspin, and the androgen receptor (AR) with demographic characteristics, pathological grade
Activin Signaling and Its Role in Regulation of Cell Proliferation, Apoptosis, and Carcinogenesis.
Chen, Y. et. Al
Exp. Biol. Med, 231, 534-544 (2006)
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