A4308

Autocamtide 2-related inhibitory peptide

≥97% (HPLC), lyophilized powder

• 동의어(들): [Ala⁹]-Autocamtide 2, AIP
• 실험식(Hill 표기법): C₆₄H₁₁₆N₂₂O₁₉
• CAS Number: 167114-91-2
• Molecular Weight: 1497.74
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329770854
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• 분석: ≥97% (HPLC)
• 형태: lyophilized powder
• 분자량: ~_1.5 kDa
• 구성: Peptide content, ≥70%
• solubility: H₂O: soluble
• 저장 온도: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)CC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O
• InChI: 1S/C65H114N20O21/c1-32(2)28-46(63(105)106)85-54(96)36(7)78-62(104)45(31-52(93)94)84-56(98)38(33(3)4)30-47(86)34(5)76-59(101)43(19-22-50(89)90)81-55(97)37(18-21-49(69)88)29-48(87)40(16-12-26-74-64(70)71)79-60(102)42(17-13-27-75-65(72)73)83-61(103)44(20-23-51(91)92)80-53(95)35(6)77-58(100)41(15-9-11-25-67)82-57(99)39(68)14-8-10-24-66/h32-46H,8-31,66-68H2,1-7H3,(H2,69,88)(H,76,101)(H,77,100)(H,78,104)(H,79,102)(H,80,95)(H,81,97)(H,82,99)(H,83,103)(H,84,98)(H,85,96)(H,89,90)(H,91,92)(H,93,94)(H,105,106)(H4,70,71,74)(H4,72,73,75)/t34-,35-,36-,37+,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1
• InChI key: COEHZSYVSXUBHI-CYZNULJVSA-N
• 유전자 정보: human ... CAMK2A(815) , CAMK2B(816) , CAMK2D(817) ; mouse ... CAMK2A(12322) , CAMK2B(12323) , CAMK2D(108058) ; rat ... CAMK2A(25400) , CAMK2B(24245) , CAMK2D(24246)

설명

Amino Acid Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

애플리케이션

Autocamtide 2-related inhibitory peptide has been used:

• To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages
• To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures
• To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII

생화학적/생리학적 작용

Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.

Potent inhibitor of calmodulin-depentent protein kinase II.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)