추천 제품
애플리케이션
- The common p.Ile291Val variant of ERLIN1 enhances TM6SF2 function and is associated with protection against MASLD.: This study investigates a variant of ERLIN1 and its role in enhancing TM6SF2 function, highlighting how Apolipoprotein B from human plasma contributes to understanding metabolic-associated liver disease (MASLD) protection (Rendel et al., 2024).
- Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations.: This prospective study evaluates the relationship between blood lipids, lipoproteins, Apolipoprotein B, and the risk of coronary heart disease across diverse populations, providing crucial insights into cardiovascular risk assessment (Deng et al., 2024).
- The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans.: Research in this paper identifies shared pathways in myeloma transformation between mice and humans, utilizing Apolipoprotein B from human plasma to understand the molecular mechanisms involved in this process (Maura et al., 2024).
생화학적/생리학적 작용
Apo-B levels correlate with the risk of coronary disease. Apo-B exists in human plasma in two isoforms, Apo-B48 and Apo-B100. Apo-B100 is the major physiological ligand for the LDL receptor. Apo-B100 is a large monomeric protein, containing 4563 amino acids (MW 515 kDa). Apo-B100 is synthesized in the liver and is required for the assembly of VLDL. It does not interchange between lipoprotein particles, as do the other apolipoproteins, and it is found in IDL and LDL after the removal of the Apo-A, E, and C. Apo-B48 is present in chylomicrons and their remnants. It is essential for the intestinal absorption of dietary lipids.
Apo-B48 is synthesized in the small intestine. It comprises approximately half of the N-terminal region of Apo-B100 and is the result of posttranscriptional mRNA editing by a stop codon in the intestine not found in the liver. The concentration of Apo-B in normal plasma is ~90 mg/dl.
Apo-B48 is synthesized in the small intestine. It comprises approximately half of the N-terminal region of Apo-B100 and is the result of posttranscriptional mRNA editing by a stop codon in the intestine not found in the liver. The concentration of Apo-B in normal plasma is ~90 mg/dl.
물리적 형태
Lyophilized from buffer containing 10 mM sodium deoxycholate, 0.05 M sodium carbonate and 0.05 M sodium chloride, pH 10.0
제조 메모
Delipidated with sodium deoxycholate.
면책조항
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Moon Kyung Choe et al.
Pharmaceuticals (Basel, Switzerland), 14(4) (2021-05-01)
Obesity is associated with autoimmunity, a phenomenon considered as harmful. Here we show that obese mice and humans produce IgG-type autoantibodies that specifically recognize apolipoprotein B-100 (ApoB100), its native epitope p210, and the synthetic p210 mimotope pB1. By contrast, antibodies
문서
Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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