A5930

N-Acetyl-Asp-Glu

≥97% (TLC)

• 동의어(들): N-Acetylaspartylglutamicacid, NAAG, Spaglumic acid
• 실험식(Hill 표기법): C₁₁H₁₆N₂O₈
• CAS Number: 3106-85-2
• Molecular Weight: 304.25
• MDL number: MFCD00076652
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24891036
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (TLC)
• 양식: powder or crystals
• 광학 활성: [α]22/D −34.5°, c = 1.1 in H₂O(lit.)
• 저장 조건: (Tightly closed. Dry)
• 색상: white to off-white
• solubility: H₂O: 50 mg/mL
• 저장 온도: −20°C
• SMILES string: CC(=O)NC(CC(O)=O)C(=O)NC(CCC(O)=O)C(O)=O
• InChI: 1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)
• InChI key: OPVPGKGADVGKTG-UHFFFAOYSA-N
• 유전자 정보: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444) , GRINA(2907) , GRM3(2913) ; mouse ... GRIN1(14810) , GRIN2A(14811) , GRIN2B(14812) , GRIN2C(14813) , GRIN2D(14814) , GRIN3A(242443) , GRIN3B(170483) , GRINA(66168) , GRM3(108069) ; rat ... GRIN1(24408) , GRIN2A(24409) , GRIN2B(24410) , GRIN2C(24411) , GRIN2D(24412) , GRIN3A(191573) , GRIN3B(170796) , GRINA(266668) , GRM3(24416)

설명

Amino Acid Sequence

NAc-Asp-Glu

일반 설명

Research area: Neuroscience

애플리케이션

N-Acetyl-Asp-Glu has been used in N-acetylated α-linked acidic dipeptidase (NAALADase) assay and affinity experiments.. It has also been used as a metabolite standard in liquid chromatography-mass spectrometry (LC-MS) targeted metabolomics analysis and mass-spectroscopy-based stable isotope-resolved metabolomics (SIRM) with 13C515N2-labeled-glutamine.

생화학적/생리학적 작용

Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR₃. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.

Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR₃; NMDA receptor antagonist.

N-Acetyl-Asp-Glu (NAAG) is an abundant neuropeptide and neurotransmitter found in the mammalian brain. NAAG acts as an agonist for metabotropic glutamate receptors, mGluR3. In addition, it also acts as an antagonist for the N-methyl d-aspartate (NMDA) receptors. It yields N-acetyl aspartate and glutamate through glutamate carboxypeptidase II (GCP II) dependent pathway. Thus, it serves as a key glutamate reservoir in cancer cells. NAAG levels in plasma could be used as a non-invasive biomarker for tumor progression.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

주의사항

Store desiccated.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves