B7563

BRD7389

≥98% (HPLC)

• 동의어(들): 1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione, 1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione
• 실험식(Hill 표기법): C₂₄H₁₈N₂O₂
• CAS Number: 376382-11-5
• Molecular Weight: 366.41
• MDL number: MFCD02924820
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: orange
• solubility: DMSO: >20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: [nH]1c2c3c(c5c([c](c3ccc2)=O)cccc5)c([c]1=O)NCCc4ccccc4
• InChI: 1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28)
• InChI key: XASCINRGTHLHGM-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

BRD7389 is an inhibitor of the RSK kinase family.

BRD7398 is a RSK kinase inhibitor that induces insulin expression and differentiation of pancreatic alpha into beta cells. BRD7398 inhibits RSK1, RSK2 and RSK3; IC50 values of 1.5, 2.4 and 1.2 uM, respectively. Treatment of mouse aTC1 cells with BRD7398 induced expression of b-cell markers Pdx1, Pax4, Iapp and Npy and also induced insulin production.

특징 및 장점

This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable