C1988

Cycloheximide

Biotechnology Performance Certified

• 동의어(들): 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• 실험식(Hill 표기법): C₁₅H₂₃NO₄
• CAS Number: 66-81-9
• Molecular Weight: 281.35
• Beilstein: 88868
• EC Number: 200-636-0
• MDL number: MFCD00082346
• UNSPSC 코드: 51102829
• PubChem Substance ID: 24892457
• NACRES: NA.85

속성

• Grade: Biotechnology Performance Certified
• Quality Level: 200
• 형태: powder
• 기술: cell culture | mammalian: suitable
• 불순물: endotoxin, tested
• solubility: ethanol: 50 mg/mL
• 항생제 활성 스펙트럼: fungi; yeast
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• InChI key: YPHMISFOHDHNIV-FSZOTQKASA-N
• 유전자 정보: human ... FKBP1A(2280) , PIN1(5300)

설명

애플리케이션

Cycloheximide is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques and activate cumulus-free equine oocytes.

생화학적/생리학적 작용

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. It inactivate transferase II enzyme that is involved in peptide chain elongation. More recent studies revealed that CHX binds the 60S ribosome and specifically prevents the translocation step in elongation.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

안전성 정보

• 픽토그램: GHS06,GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H300,H341,H360D,H411
• 예방조치 성명서: P201 - P202 - P264 - P270 - P273 - P301 + P310
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges