C2970

Monoclonal Anti-Cathepsin L antibody produced in mouse

clone 33/2, ascites fluid

• 동의어(들): Anti-CATL, Anti-CTSL, Anti-MEP
• MDL number: MFCD01321805
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: 33/2, monoclonal
• 분자량: antigen (human cathepsin L) 25 kDa; antigen (human procathepsin L) 42 kDa
• 포함: 15 mM sodium azide
• 종 반응성: mouse, mink, human, rat
• 기술: immunohistochemistry (frozen sections): suitable; indirect ELISA: suitable; microarray: suitable; western blot: 1:200 using whole cell extract of a cultured mink lung cell line
• 동형: IgG1
• UniProt 수납 번호: P07711
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CTSL1(1514) ; mouse ... Ctsl(13039) ; rat ... Ctsl1(25697)

설명

일반 설명

Cathepsin L is a cysteine protease and is secreted by numerous transformed cells in its inactive pre-form. It is ubiquitously expressed and is localized in nucleus. Cathepsin L have substrate interacting region located in L and R domain loops.

특이성

Reacts specifically with native and denatured forms of human cathepsin L and procathepsin L. Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). The antibody may be used for the suppression of the malignant growth of myeloma cells. Cross-reactivity is observed with rat cathepsin L (strong), mouse procathepsin L (weak) and mink cathepsin and procathepsin L. Does not cross-react with human cathepsin types B, D, H and S, procathepsins B and D, rat cathepsin B, and mouse procathepsins B and D.

면역원

procathepsin L isolated from the human lung cancer cell line EPLC 32M1.

생화학적/생리학적 작용

Cathepsin L expression is correlated with the metastatic potential of transformed cells. Cathepsin L is capable of degrading protein constituents of the extracellular matrix, this enzyme is thought to play a crucial role in tumor progression, metastasis and other disorders where the destruction of the matrix is the major cause of disease.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable