추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
저장 조건
desiccated
색상
white to off-white
solubility
DMSO: >20 mg/mL
H2O: >20 mg/mL
주관자
Wyeth
저장 온도
2-8°C
SMILES string
Cl.CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2
InChI
1S/C16H25NO2.ClH/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1H
InChI key
IMWPSXHIEURNKZ-UHFFFAOYSA-N
애플리케이션
Desvenlafaxine hydrochloride has been used to evaluate if its occurrence in drinking water at environmental concentrations could induce neuronal gene expression.
생화학적/생리학적 작용
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.
Desvenlafaxine hydrochloride is a psychoactive drug. Incidence of this drug in environmental samples might induce in vitro gene expression associated with neurological disorders.
특징 및 장점
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations
Neuroscience Letters, 661(3), 143-148 (2017)
Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders
BMC Genomics, 17(3), 435-435 (2016)
International journal of environmental research and public health, 18(13) (2021-07-03)
Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an understudied area and entails one of the most complex areas in toxicology. Animal studies for developmental neurotoxicity (DNT) are
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