D9766

Dipyridamole

≥98% (HPLC), powder, phosphodiesterase V inhibitor

• 동의어(들): NSC 515776, NSC 619103
• 실험식(Hill 표기법): C₂₄H₄₀N₈O₄
• CAS Number: 58-32-2
• Molecular Weight: 504.63
• EC Number: 200-374-7
• MDL number: MFCD00010555
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24277705
• NACRES: NA.77

속성

• product name: Dipyridamole, ≥98% (HPLC)
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: yellow
• mp: 165-166 °C (lit.)
• solubility: DMSO: soluble; ethanol: soluble
• 주관자: Boehringer Ingelheim
• 저장 온도: room temp
• SMILES string: OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
• InChI: 1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
• InChI key: IZEKFCXSFNUWAM-UHFFFAOYSA-N
• 유전자 정보: human ... CYP1A2(1544) , PDE10A(10846) , PDE1A(5136) , PDE1B(5153) , PDE1C(5137) , PDE2A(5138) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE6A(5145) , PDE6B(5158) , PDE6C(5146) , PDE6D(5147) , PDE6G(5148) , PDE6H(5149) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622) , PDE9A(5152) , SLC29A1(2030) ; mouse ... Slc29a1(63959)

설명

일반 설명

Dipyridamole prevents cellular uptake of adenosine. It functions as an equilibrative nucleoside transporter 1 (ENT1) inhibitor.

애플리케이션

Dipyridamole has been used:

• to perform in vitro growth inhibition assay(40)
• to determine its ability to prevent uterine myometrial contractions(41)
• to determine its effects on nicotinamide adenine dinucleotide (NAD+)-induced increase in intracellular adenosine triphosphate (ATP) levels(42)
• to prevent nicotinamide riboside (NR)-induced axonal protection(43)

생화학적/생리학적 작용

Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves