추천 제품
생물학적 소스
human plasma
Quality Level
분석
>90% (SDS-PAGE)
양식
lyophilized powder
분자량
70 kDa
포장
pkg of 0.5 mg
기술
cell culture | mammalian: suitable
불순물
HIV and HBsAg, source material tested negative
Small proteolytic fragments, may contain traces
solubility
water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless
UniProt 수납 번호
배송 상태
ambient
저장 온도
−20°C
유전자 정보
human ... FN1(2335)
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일반 설명
Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.
애플리케이션
Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.
생화학적/생리학적 작용
Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.
주의사항
The product should be stored at -20°C.
제조 메모
This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
Fibronectin in Health and Disease (2018)
Mutations F352A and Y528A in human HSP90I? reduce fibronectin association and fibrillogenesis in cell-derived matrices.
Chakraborty, et al.
Cell Stress & Chaperones (2023)
C Penn et al.
Microbial pathogenesis, 17(6), 387-393 (1994-12-01)
Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
Stratman A N, et al.
Blood, 114(24), 5091-5101 (2009)
Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120 kDa region of fibronectin to facilitate cell binding by Yersinia pestis.
Tsang T M, et al.
The Journal of Biological Chemistry, 287(20), 16759-16767 (2012)
프로토콜
Dilute fibronectin for cell attachment, varying per cell type. Coating protocol, products, and FAQs provided.
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