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Merck
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주요 문서

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F3254

Sigma-Aldrich

Fibrinopeptide A human

≥96% (HPLC)

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About This Item

실험식(Hill 표기법):
C63H97N19O26
CAS Number:
25422-31-5
Molecular Weight:
1536.56
MDL number:
MFCD00076437
UNSPSC 코드:
12352202
PubChem Substance ID:
24894837
NACRES:
NA.77

생물학적 소스

human

Quality Level

200

분석

≥96% (HPLC)

형태

powder

기술

ELISA: suitable
mass spectrometry (MS): suitable

UniProt 수납 번호

P02671

저장 온도

−20°C

SMILES string

CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(C)N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(O)=O

InChI

1S/C63H97N19O26/c1-29(2)19-37(57(102)73-32(6)53(98)76-35(15-17-48(91)92)55(100)70-24-43(85)68-23-42(84)69-25-46(88)82-51(30(3)4)61(106)77-36(62(107)108)13-10-18-67-63(65)66)79-58(103)38(20-33-11-8-7-9-12-33)80-59(104)39(21-49(93)94)75-45(87)27-71-54(99)34(14-16-47(89)90)74-44(86)26-72-56(101)41(28-83)81-60(105)40(22-50(95)96)78-52(97)31(5)64/h7-9,11-12,29-32,34-41,51,83H,10,13-28,64H2,1-6H3,(H,68,85)(H,69,84)(H,70,100)(H,71,99)(H,72,101)(H,73,102)(H,74,86)(H,75,87)(H,76,98)(H,77,106)(H,78,97)(H,79,103)(H,80,104)(H,81,105)(H,82,88)(H,89,90)(H,91,92)(H,93,94)(H,95,96)(H,107,108)(H4,65,66,67)

InChI key

JWICNZAGYSIBAR-UHFFFAOYSA-N

유전자 정보

human ... FGA(2243)

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Amino Acid Sequence

Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg

일반 설명

Fibrinopeptide A (FPA) is produced from the N-terminal Aα region of fibrinogen protein, on cleavage by thrombin. It is composed of 16 amino acids.

애플리케이션

Fibrinopeptide A human has been used for protein control experiments performed during sandwich ELISA microarray assay to distinguish between plasma and serum fibrinogen samples. It has also been used in a peptide mixture along with BSA (bovine serum albumin) to ascertain the relation between fragmentation voltage and peptide ion drift time for IMS-MS (ion mobility spectrometry coupled with mass spectrometry).

생화학적/생리학적 작용

Fibrinogen plays essential roles in coagulation of blood, wound healing, platelet aggregation and has roles in various other physiological processes. Increase in the levels of fibrinopeptide A (FPA) is found in multiple disorders such as coronary artery disease, disseminated intravascular coagulation, arterial thrombosis, deep venous thrombosis and cancers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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Fluorescein isothiocyanate isomer I suitable for protein labeling, ≥90% (HPLC), powder

Sigma-Aldrich

F7250

Fluorescein isothiocyanate isomer I

Xi Chen et al.
Environmental toxicology and pharmacology, 33(2), 191-196 (2012-01-10)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine disruptors. To investigate peptide changes in the sera of rats chronically exposed to TCDD and to explore the association of these changes with liver morphology, TCDD was administrated to male rats at doses
H L Nossel et al.
The Journal of clinical investigation, 54(1), 43-53 (1974-07-01)
Since thrombin cleaves fibrinopeptides A (FPA) and B from the NH(2)-terminal end of the fibrinogen molecule, measurement of fibrinopeptide levels in plasma may provide a direct index of thrombin action. Recently a radioimmunoassay for FPA has been developed, and in
Laura A Da Costa et al.
The Journal of nutritional biochemistry, 24(1), 396-400 (2012-12-04)
Vitamin E is a lipophilic antioxidant that has been inversely associated with certain chronic diseases; however, the biological processes regulated by this vitamin have not been fully elucidated. The objective of the present study was to examine the association between
J I Weitz
Thrombosis and haemostasis, 75(4), 529-535 (1996-04-01)
There is good evidence that thrombolytic therapy induces a procoagulant state that retards the lytic process and triggers reocclusion. Thus, both in experimental animal systems and in humans, potent inhibitors of platelets and antithrombin III-independent thrombin inhibitors have been shown
P R Eisenberg et al.
Circulation, 71(5), 912-918 (1985-05-01)
To determine whether coronary thrombosis in vivo is reflected by elevations in levels of fibrinopeptide A (FPA) in plasma, we sequentially characterized plasma FPA levels associated with evolving infarction in patients admitted to the cardiac care unit early after the
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