추천 제품
생물학적 소스
human pituitary glands
Quality Level
무균
non-sterile
형태
powder
특이 활성도
~7,000 IU/mg (powder)
분자량
35 kDa
기술
cell culture | mammalian: suitable
불순물
HBsAg, HCV and HIV-1/HIV-2, tested negative
pH
7.4
solubility
water: ~50 g/L
배송 상태
ambient
저장 온도
−20°C
유전자 정보
human ... FSHB(2488) , FSHR(2492)
일반 설명
The α chain of FSH has 89 amino acids and the β chain has 115 amino acids. The α chain is not active. FSH belongs to glycoprotein hormone family. It is secreted by the gonadotropic cells of pituitary gland.
Research area: Cell signaling
Research area: Cell signaling
애플리케이션
Follicle stimulating hormone (FSH) from human pituitary has been used for-
- in vitro luteinization of Macaque granulosa cells
- luteal cell proliferation assay
- culturing of preantral follicle cells obtained from mice
- in vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice and
- culture of RAW264.7 cell line
생화학적/생리학적 작용
FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle-stimulating hormone receptor) interacts with FSH in the ovaries and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In the Caucasian population, certain polymorphisms in the FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS). In the male fetuses and neonates, it facilitates the proliferation of Sertoli cells. In pubescent males, it stimulates spermatogonia to undergo mitosis.FSH upon binding to its receptor FSH-R positively regulates G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to cascade intracellular signals.
The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
포장
Package size based on protein content
기타 정보
Two-chain glycoprotein hormone
품질
Vial also contains 0.1 mg of salts from 0.05 M phosphate buffer, pH 7.4.
항체
제품 번호
설명
가격
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Karenne N Fru et al.
Biology of reproduction, 75(4), 568-574 (2006-07-14)
Ovulation and luteal formation in primates are associated with the sustained synthesis of progesterone. The observed high intrafollicular concentrations of progesterone during the periovulatory interval raise the possibility that this steroid serves as a precursor for mineralocorticoids. The aim of
Y Figenschau et al.
Human reproduction (Oxford, England), 12(3), 523-531 (1997-03-01)
A simplified method for the preparation and long-term cultivation of granulosa-luteal cells in serum-free medium is described. The cells were harvested from women undergoing in-vitro fertilization, enriched by sedimentation and dissociated by enzymatic treatment. We demonstrated, by introducing a synthetic
J Wu et al.
Biology of reproduction, 63(1), 320-327 (2000-06-22)
Although it is known that LH receptors are present from the time of thecal differentiation, the role of LH during early follicle development is not yet clear. The effect of LH on preantral follicle development has therefore been investigated in
Wanakan Singhasena et al.
Reproductive biology and endocrinology : RB&E, 12, 86-86 (2014-09-03)
Polymorphisms at codons 307 and 680 are the most commonly encountered allelic variants of the follicle-stimulating hormone receptor (FSHR) gene. Studies in Caucasians suggest that certain FSHR variants are more common in women with polycystic ovary syndrome (PCOS) than normal
Michele Morelli et al.
Gynecologic oncology, 129(3), 448-451 (2013-04-06)
The objective of this study is to compare ovarian function and surgical outcomes between patients affected by benign uterine pathologies submitted to total laparoscopic hysterectomy (TLH) plus salpingectomy and women in which standard TLH with adnexal preservation was performed. We
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