H0165

7-Ethyl-10-hydroxycamptothecin

powder, ≥98% (HPLC)

• 동의어(들): SN-38
• 실험식(Hill 표기법): C₂₂H₂₀N₂O₅
• CAS Number: 86639-52-3
• Molecular Weight: 392.40
• MDL number: MFCD00871873
• UNSPSC 코드: 12352204
• PubChem Substance ID: 329815105
• NACRES: NA.77

속성

• 제품명: 7-Ethyl-10-hydroxycamptothecin, ≥98% (HPLC), powder
• 생물학적 소스: Artemisia annua
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• solubility: DMSO: 1 mg/mL
• 저장 온도: −20°C
• SMILES string: OC1=CC2=C(CC)C(C3)=C(N=C2C=C1)C(N3C4=O)=CC5=C4COC([C@]5(O)CC)=O
• InChI: 1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
• InChI key: FJHBVJOVLFPMQE-QFIPXVFZSA-N

설명

애플리케이션

7-Ethyl-10-hydroxycamptothecin has been used:

• to inhibit enterovirus 71 (EV71) (H) infection
• to screen the chemosensitivity of pancreatic adenocarcinoma cells
• as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters

생화학적/생리학적 작용

Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H360D,H372
• 예방조치 성명서: P201 - P202 - P260 - P264 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B - STOT RE 1
• 표적 기관: Gastro-intestinal system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)