H6012
4-Hydroxyestrone
≥90% (HPLC)
동의어(들):
1,3,5(10)-Estratriene-3,4-diol-17-one
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H22O3
CAS 번호:
Molecular Weight:
286.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
제품 이름
4-Hydroxyestrone, ≥90% (HPLC)
InChI
1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-,12-,14+,18+/m1/s1
SMILES string
[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc4c(O)c(O)ccc24
InChI key
XQZVQQZZOVBNLU-QDTBLXIISA-N
sterility
non-sterile
assay
≥90% (HPLC)
form
powder
solubility
methanol: 10 mg/mL, clear, colorless to faintly brownish-yellow
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
4-Hydroxyestrone is an endogenous estrogen metabolite, which exhibits a strong neuroprotective effect against oxidative damage. It also provides effective protection against kanic acid-induced hippocampal oxidative damage in rats when compared to 17β-estradiol. 4-Hydroxyestrone regulates the angiogenic process during corpus luteum formation. It might be involved in an increased risk of cancer. 4-Hydroxyestrone is found in the early and mid-luteal phases.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
199.9 °F - closed cup
flash_point_c
93.3 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
Y Markushin et al.
The Prostate, 66(14), 1565-1571 (2006-08-09)
Catechol estrogen quinones (CEQ) derived from 4-hydroxyestrone (4-OHE1) and 4-hydroxyestradiol (4-OHE2) react with DNA to form depurinating--N7Gua and--N3Ade adducts. This damage leads to mutations that can initiate breast and prostate cancer. To determine whether this damage occurs in humans, urine
Z Cheng et al.
Toxicological sciences : an official journal of the Society of Toxicology, 45(1), 52-57 (1998-12-16)
Catechol estrogens are major estrogen metabolites in mammals and are the most potent naturally occurring inhibitors of catecholamine metabolism. These estrogen compounds have been implicated in carcinogenic activity and the 4/2-hydroxyestradiol concentration has been shown to be elevated in neoplastic
K Tabakovic et al.
Chemical research in toxicology, 7(5), 696-701 (1994-09-01)
Reaction of lysine with estrone 3,4-o-quinone gave a complex mixture of products. Six compounds were isolated and identified using spectroscopic techniques. Among the reaction products isolated were 4-hydroxyestrone (2), 3-aminoisoestrone (3), 3-(N-pentyl-5-amino)-isoestrone (4), 1-lysylestrone 3,4-o-iminoquinone (5), and two dimeric products
E Pisha et al.
Chemical research in toxicology, 14(1), 82-90 (2001-02-15)
Estrogen replacement therapy has been correlated with an increased risk of developing hormone-dependent cancers. 4-Hydroxyequilenin (4-OHEN) is a catechol metabolite of equilenin and equilin which are components of the estrogen replacement formulation marketed under the name of Premarin (Wyeth-Ayerst). Previously
B T Zhu et al.
Endocrinology, 135(5), 1772-1779 (1994-11-01)
As part of an ongoing investigation of the role of metabolic activation of estrogens in the genesis of cancers such as estrogen-induced renal tumors in hamsters, we have 1) determined steroid-17 beta-oxidoreductase activity of microsomes and cytosol prepared from hamster
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