HPA021451
Anti-SLC16A3 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
동의어(들):
Anti-MCT 3, Anti-MCT 4, Anti-Monocarboxylate transporter 3, Anti-Monocarboxylate transporter 4, Anti-Solute carrier family 16 member 3
로그인조직 및 계약 가격 보기
모든 사진(6)
About This Item
추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
제품 라인
Prestige Antibodies® Powered by Atlas Antibodies
양식
buffered aqueous glycerol solution
종 반응성
rat, human, mouse
기술
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
면역원 서열
AEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... SLC16A3(9123)
일반 설명
The gene SLC16A3 (solute carrier family 16 member 3) is mapped to human chromosome 17q25.3. It belongs to the SLC16A family and is a transmembrane protein. SLC16A3 is expressed in testis, small intestine, lung, brain, heart, kidney, and spleen. SLC16A3 is commonly referred to as MCT4 (monocarboxylate transporter 4).
면역원
Monocarboxylate transporter 4 recombinant protein epitope signature tag (PrEST)
애플리케이션
Anti-SLC16A3 antibody produced in rabbit has been used in: immunohistochemistry, flow cytometry, and immunofluorescence (IF) confocal microscopy to stain human bronchial epithelial cells (HBECs)-short hairpin RNA (shRNA) targeting TP53(shp53 (shp53)-V5-TMPRSS11B cells.
생화학적/생리학적 작용
MCTs (monocarboxylate transporters) are important for transporting lactate and other monocarboxylates across the cell membrane. MCT4/SLC16A3 (solute carrier family 16 member 3) is involved in the transport of γ-hydroxybutyric acid and L-lactate. SLC16A3 is up-regulated in triple negative breast cancer. It is responsible for maintenance of pH, lactate secretion and non-oxidative metabolism of glucose in cancer cells. In similar manner, androgens induce glycolytic metabolism and lactate export in prostate cancer cells by regulating SLC16A3 expression.
특징 및 장점
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
결합
Corresponding Antigen APREST75671
물리적 형태
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
법적 정보
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Irina Heid et al.
Cancer & metabolism, 10(1), 24-24 (2022-12-11)
Pancreatic ductal adenocarcinoma (PDAC) lacks effective treatment options beyond chemotherapy. Although molecular subtypes such as classical and QM (quasi-mesenchymal)/basal-like with transcriptome-based distinct signatures have been identified, deduced therapeutic strategies and targets remain elusive. Gene expression data show enrichment of glycolytic
J Doyen et al.
Biochemical and biophysical research communications, 451(1), 54-61 (2014-07-25)
(18)Fluor-deoxy-glucose PET-scanning of glycolytic metabolism is being used for staging in many tumors however its impact on prognosis has never been studied in breast cancer. Glycolytic and hypoxic markers: glucose transporter (GLUT1), carbonic anhydrase IX (CAIX), monocarboxylate transporter 1 and
Chantale Farah et al.
Biomedicines, 10(3) (2022-03-26)
A vast majority of BRAF V600E mutated melanoma patients will develop resistance to combined BRAF/MEK inhibition after initial clinical response. Resistance to targeted therapy is described to be accompanied by specific metabolic changes in melanoma. The aim of this work
Barbora Peltanová et al.
Cancers, 14(9) (2022-05-15)
Head and neck squamous cell carcinomas (HNSCC) belong among severe and highly complex malignant diseases showing a high level of heterogeneity and consequently also a variance in therapeutic response, regardless of clinical stage. Our study implies that the progression of
Shouyu Wang et al.
Forensic science international, 270, 165-172 (2016-12-18)
Sudden unexplained death (SUD) constitutes a part of the overall sudden death that can not be underestimated. Over the last years, genetic testing on SUD has revealed that inherited channelopathies might play important roles in the pathophysiology of this disease.
문서
Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.