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Merck
모든 사진(1)

주요 문서

I4902

Sigma-Aldrich

Anti-Interferon-α/β Receptor 1 antibody produced in goat

affinity isolated antibody, lyophilized powder

동의어(들):

Anti-IFN-α/β R1

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About This Item

MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.41

생물학적 소스

goat

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

lyophilized powder

종 반응성

human

기술

flow cytometry: suitable (1-10μg/106 cells)
western blot: 0.1-1 μg/mL

UniProt 수납 번호

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... IFNAR1(3454)

일반 설명

Interferon-α/β Receptor 1 is a dimeric, disulfide-linked protein that binds human interferons α and β. This receptor also interacts with Tyr kinase JAK1, and thereby regulates cellular signaling across the membranes . Anti-Interferon-α/β Receptor 1 is specific for recombinant human IFN-α/β R1 and does not react with recombinant human IFN-γ RI and IFN-γ RII.

면역원

recombinant human IFN-α/β R1 extracellular domain expressed in Sf21 insect cells.

애플리케이션

Anti-Interferon-α/β Receptor 1 antibody is suitable for usein flow cytometry (1-10μg/106 cells) and western blot (0.1-1 μg/mL). Theantibody may also be used for immunoblotting (approx. 135kDa) and indirectimmunofluorescence (using appropriate secondary antibodies).

물리적 형태

0.1-1 μg/mL Recombinant Human IFN-α/β R1, HeLa humancervical epithelial carcinoma cell line, K562 human chronic myelogenousleukemia cell line.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

S N Constantinescu et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(20), 9602-9606 (1994-09-27)
A previously cloned cDNA encodes one subunit of the human interferon alpha/beta receptor (IFN alpha R), denoted IFN alpha R1. To study the expression and signaling of IFN alpha R1, we used monoclonal antibodies (mAbs) generated against the baculovirus-expressed ectodomain
D Novick et al.
Cell, 77(3), 391-400 (1994-05-06)
We describe a universal ligand-binding receptor for human interferons alpha and interferon beta (type I IFNs). A soluble 40 kDa IFN-alpha/beta receptor (p40) that blocks the activity of type I IFNs was purified from urine and sequenced. Antibodies raised against

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