I7018

3-Isobutyl-1-methylxanthine

BioUltra, ≥99%

• 동의어(들): 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX
• 실험식(Hill 표기법): C₁₀H₁₄N₄O₂
• CAS Number: 28822-58-4
• Molecular Weight: 222.24
• Beilstein: 247859
• EC Number: 249-259-3
• MDL number: MFCD00005584
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24896107
• NACRES: NA.77

속성

• 제품 라인: BioUltra
• Quality Level: 200
• 분석: ≥99%
• 불순물: <0.005% Phosphorus (P)
• 무기 잔류물: <0.1%
• mp: 200-201 °C (lit.)
• solubility: DMSO: soluble 1 M (with gentle warming)
• 음이온 미량물: sulfate (SO₄^2-): <0.05%
• 양이온 미량물: Al: <0.0005%; Ca: <0.005%; Cu: <0.0005%; Fe: <0.005%; K: <0.05%; Mg: <0.005%; NH₄⁺: <0.05%; Na: <0.005%; Pb: <0.001%; Zn: <0.0005%
• 저장 온도: −20°C

설명

애플리케이션

3-Isobutyl-1-methylxanthine, an inhibitor of adenosine 3′,5′-cyclic monophosphate phosphodiesterase (cAMP PDE), has been used:

• for adipogenic differentiation[1]
• in tissue culture[2]
• 3T3-L1 preadipocyte differentiation([3]

생화학적/생리학적 작용

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC₅₀: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

특징 및 장점

• Trace element testing by ICP
• ICP testing for trace sulfur (as sulfate) and phosphorus (as phosphate) content
• Ion chromatography testing for trace ammonium content

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves