J4580

Jasplakinolide

≥97% (HPLC), film (colorless), actin polymerization promoter

• 동의어(들): Jaspamide
• 실험식(Hill 표기법): C₃₆H₄₅BrN₄O₆
• CAS Number: 102396-24-7
• Molecular Weight: 709.67
• MDL number: MFCD00873735
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329815735
• NACRES: NA.77

속성

• product name: Jasplakinolide, ≥97% (HPLC)
• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: film (colorless)
• 색상: off-white to beige
• solubility: DMSO: >2 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: C[C@H]1C[C@@H](C)\C=C(C)\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c4ccc(O)cc4
• InChI: 1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1
• InChI key: GQWYWHOHRVVHAP-DHKPLNAMSA-N

설명

애플리케이션

Jasplakinolide has been used to analyze its influence on sciatic nerve guidance effect in vivo in chicken embryos. It has also been used to apply on the control cells for the treatment for blocking actin dynamics.

생화학적/생리학적 작용

Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable