L1168

Anti-phospho-5-Lipoxygenase (pSer⁵²³) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• MDL number: MFCD08705494
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous glycerol solution
• 종 반응성: human, rat
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunoprecipitation (IP): suitable; indirect immunofluorescence: suitable; western blot: 1:1,000
• UniProt 수납 번호: P09917
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... ALOX5(240) ; rat ... Alox5(25290)

설명

일반 설명

The gene ALOX5 (arachidonate 5-lipoxygenase), also referred to as 5-LOX (5-lipoxygenase), encodes a protein belonging to the lipoxygenase family. The gene is mapped to human chromosome 10q11.21. The protein contains a distinct ‘C2-like′ domain at the amino terminal that is involved in Ca²⁺-dependent membrane binding and a large catalytic domain containing the non-heme catalytic iron. It is highly unstable with short-lived activity.

면역원

phosphopeptide corresponding to amino acid residues surrounding the pSer⁵²³ of human 5-lipoxgenase (5-LO).

애플리케이션

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

생화학적/생리학적 작용

The gene ALOX5 (arachidonate 5-lipoxygenase) encodes a lipoxygenase that catalyzes the conversion of arachidonic acid (AA) and other fatty acids to bioactive compounds, such as 5(S)-hydroxyeicosatetraenoic acid (5-HETE), leukotriene B4 (LTB4), and other leukotrienes. These leukotrienes and lipoxins function as mediators of inflammatory response. ALOX5 has been implicated in tumorigenesis and may serve as a potential therapeutic target and biomarker.

물리적 형태

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)