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Merck
모든 사진(2)

주요 문서

L3265

Sigma-Aldrich

Lipoteichoic acid from Bacillus subtilis

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About This Item

CAS Number:
MDL number:
UNSPSC 코드:
12352211
NACRES:
NA.25

생물학적 소스

Bacillus subtilis

Quality Level

형태

lyophilized powder

지질 유형

polymerizable lipids

배송 상태

ambient

저장 온도

2-8°C

생화학적/생리학적 작용

Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of gram-positive bacteria. Lipoteichoic acid from Bacillus subtilis may be used to compare its structure, immunogenicity and functions versus other bacterial LTAs.
Lipoteichoic acid (LTA) is a teichoic acid attached to a lipid abundant on Gram-positive bacteria cell wall. LTA is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

Mardi A Crane-Godreau et al.
Infection and immunity, 73(1), 476-484 (2004-12-25)
Having previously shown that CCL20/macrophage inflammatory protein 3alpha and tumor necrosis factor alpha (TNF-alpha) are released by polarized primary rat uterine epithelial cells (UEC) in response to Escherichia coli but not to Lactobacillus rhamnosus, we sought to determine if epithelial
Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria.
Zidek Z, Farghali H, Kmonickova E.
Nitric Oxide, 232, 300-310 (2010)
Young Hee Ryu et al.
International immunopharmacology, 9(1), 127-133 (2008-11-18)
Lipoteichoic acid (LTA) is a major immunostimulating component in the cell wall of Gram-positive bacteria as lipopolysaccharide of Gram-negative bacteria. However, LTA is expressed on not only pathogenic but also nonpathogenic Gram-positive bacteria. In order to examine whether the immunostimulating
Xiang-Jun Rao et al.
Developmental and comparative immunology, 34(10), 1119-1128 (2010-07-06)
Activation of prophenoloxidase and synthesis of antimicrobial peptides (AMPs) are two important innate immune mechanisms in insects. In the current study, we investigated immune responses activated by three major bacterial components, lipopolysaccharide (LPS) (including rough mutants of LPS), lipoteichoic acid
Siegfried Morath et al.
Journal of endotoxin research, 11(6), 348-356 (2005-11-24)
The role of lipoteichoic acids (LTAs) from Gram-positive bacteria as immunostimulatory molecules was controversial for many years, as inadequate preparation methods as well as heterogeneous and endotoxin-contaminated commercial preparations led to conflicting results. An improved purification methodology for LTA now

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