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Merck
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주요 문서

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M149

Sigma-Aldrich

Methiothepin mesylate salt

≥98% (HPLC), solid

동의어(들):

1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine mesylate salt, Metitepine mesylate salt

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About This Item

Linear Formula:
C20H24N2S2 · CH3SO3H
CAS Number:
74611-28-2
Molecular Weight:
452.65
MDL number:
MFCD00153831
UNSPSC 코드:
12352200
PubChem Substance ID:
24278104
NACRES:
NA.77
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Quality Level

100

분석

≥98% (HPLC)

양식

solid

저장 조건

desiccated

색상

white

solubility

H2O: 13 mg/mL

SMILES string

CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1

InChI

1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)

InChI key

CZMDZGZYKOGLJY-UHFFFAOYSA-N

유전자 정보

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR6(3362) , HTR7(3363)

일반 설명

Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.[1]

애플리케이션

Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche.[2] It has also been used in serotonin (5-HT) and antagonists in vivo bioassays[3] and in in vivo antagonist and lipopolysaccharide stimulations.[4]

생화학적/생리학적 작용

Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000322136
0000322135
0000329349
0000322136
0000322135

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문서 라이브러리 방문

T Nilsson et al.
European journal of pharmacology, 372(1), 49-56 (1999-06-22)
5-Hydroxytryptamine (5-HT) can produce both vasoconstrictor and vasorelaxant effects in human coronary arteries and the response to 5-HT can be influenced by the presence of disease. The aim of the present study was to elucidate the 5-HT receptor subtypes responsible
A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas
Jia Y, et al.
Developmental and Comparative Immunology, 82, 83-93 (2018)
Blockade of central 5-hydroxytryptamine receptors by methiothepin
Monachon M A, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 274(2), 192-197 (1972)
D J McLoughlin et al.
Journal of neurochemistry, 74(1), 347-357 (2000-01-05)
Mechanisms of agonist and inverse agonist action at the serotonin 5-HT1A receptor have been studied using the modulation of guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS) binding in membranes of Chinese hamster ovary (CHO) cells expressing the receptor (CHO-5-HTA1A cells). A range of agonists
F G Boess et al.
Molecular pharmacology, 54(3), 577-583 (1998-09-09)
Ro 63-0563 [4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulfonamide] is a high affinity 5-hydroxytryptamine6 (HT6) receptor antagonist with more than 100-fold selectivity for the 5-HT6 receptor compared with 69 other receptors and binding sites. The present study describes the properties of [3H]Ro 63-0563, the
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