Skip to Content
MilliporeSigma
All Photos(1)

Documents

O3639

Sigma-Aldrich

Ondansetron hydrochloride dihydrate

≥98% (HPLC), powder, 5-HT₃serotonin receptor antagonist

Sign Into View Organizational & Contract Pricing

Synonym(s):
1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride, GR 38032F
Empirical Formula (Hill Notation):
C18H19N3O · HCl · 2H2O
CAS Number:
Molecular Weight:
365.85
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: >5 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C

InChI

1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2

InChI key

VRSLTNZJOUZKLX-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359)

Looking for similar products? Visit Product Comparison Guide

Application

Ondansetron hydrochloride dihydrate has been used as a 5-HT3 antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT3 protein.

Biochem/physiol Actions

Ondansetron, (3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl] 1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dehydrate acts as a selective 5-hydroxytryptamine type 3 (5-HT3) serotonin receptor antagonist. It is used as an antiemetic to control nausea and vomiting associated with chemotherapy and radiotherapy.
5-HT3 serotonin receptor antagonist

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 7

1 of 7

Ondansetron impurity D European Pharmacopoeia (EP) Reference Standard

Y0000195

Ondansetron impurity D

Ondansetron impurity E European Pharmacopoeia (EP) Reference Standard

Y0001326

Ondansetron impurity E

Ondansetron Related Compound C United States Pharmacopeia (USP) Reference Standard

USP

1478618

Ondansetron Related Compound C

Ondansetron Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1478593

Ondansetron Related Compound A

Ondansetron impurity F European Pharmacopoeia (EP) Reference Standard

Y0001320

Ondansetron impurity F

Ondansetron hydrochloride dihydrate British Pharmacopoeia (BP) Reference Standard

BP808

Ondansetron hydrochloride dihydrate

Alcohol-induced serotonergic modulation: the role of histone deacetylases
Agudelo M
Alcohol, 46(7), 635-642 (2012)
Aruna Sharma et al.
Molecular neurobiology, 52(2), 867-881 (2015-07-03)
Military personnel are often subjected to sleep deprivation (SD) during combat operations. Since SD is a severe stress and alters neurochemical metabolism in the brain, a possibility exists that acute or long-term SD will influence blood-brain barrier (BBB) function and
J H Ye et al.
CNS drug reviews, 7(2), 199-213 (2001-07-28)
Ondansetron is a selective 5-hydroxytryptamine(3) (5-HT(3)) receptor antagonist that has been introduced to clinical practice as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting. Its use under these circumstances is both prophylactic and therapeutic. It has a superior
Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E2 in the spinal cord.
Marshall TM
Pain, 153(1), 86-94 (2012)
ION-PAIR REVERSED-PHASE HIGHPERFORMANCE
LIQUID CHROMATOGRAPHY
OF ONDANSETRON HYDROCHLORIDE USING
SODIUM HEPTANESULPHONATE AS A
COUNTERION
varvara A
Farmacia, 57, 4, 442-451 (2009)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service