추천 제품
제품명
1-Methylhistamine dihydrochloride, ≥98% (TLC), powder
Quality Level
분석
≥98% (TLC)
양식
powder
solubility
water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
저장 온도
2-8°C
SMILES string
Cl[H].Cl[H].Cn1cnc(CCN)c1
InChI
1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChI key
AGXVEALMQHTMSW-UHFFFAOYSA-N
유전자 정보
human ... HRH1(3269) , HRH2(3274) , HRH3(11255) , HRH4(59340)
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애플리케이션
1-Methylhistamine dihydrochloride has been used as a standard in the evaluation of histamine levels in aqueous humor of glaucoma patients by liquid chromatography. It has also been used as a substrate to determine amine oxidase activity.
생화학적/생리학적 작용
1-Methylhistamine is present in the brain and is a metabolite of histamine that is metabolized by histamine N-methyltransferase. It acts as a biomarker for histaminergic system activity in the cerebrospinal fluid of patients suffering from Alzheimer′s disease (AD), hypersomnia, and other neurological conditions.
Major metabolite of histamine by histamine N-methyltransferase.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Y Hashimoto et al.
Acta anaesthesiologica Scandinavica, 42(7), 858-863 (1998-08-12)
Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate
Inability to replicate cerebrospinal fluid histamine deficits in the primary hypersomnias: a back to the drawing board moment.
David B Rye
Sleep, 35(10), 1315-1317 (2012-10-02)
M Motawaj et al.
The Journal of pharmacology and experimental therapeutics, 336(2), 479-487 (2010-11-09)
We previously reported that some N-methyl-D-aspartate (NMDA)-receptor antagonists enhanced histamine neuron activity in rodents. Here, we have investigated the effects of memantine, an NMDA-receptor antagonist used for the treatment of Alzheimer's disease, on histaminergic neurotransmission. In vitro, memantine antagonized native
Yasuhisa Miyamoto et al.
Analytical biochemistry, 334(1), 89-96 (2004-10-07)
An improved high-performance liquid chromatography (HPLC) method was developed for simultaneous analysis of histamine (HA) and tele-methylhistamine (tele-MHA) levels in mouse and rat brain. The method consists of a solid-phase extraction (SPE) and subsequent HPLC with postcolumn derivatization of the
A Burban et al.
The Journal of pharmacology and experimental therapeutics, 332(3), 912-921 (2009-12-17)
Histamine potentiates activation of native and recombinant N-methyl-d-aspartate receptors (NMDARs), but its mechanisms of action and physiological functions in the brain remain controversial. Using four different models, we have further investigated the histamine-induced potentiation of various NMDAR-mediated responses. In single
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