P0749

Anti-Potassium Channel K_v11.1 Extracellular antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 동의어(들): Anti-HERG, Anti-KCNH2
• MDL number: MFCD02097212
• UNSPSC 코드: 12352203
• NACRES: NA.41
• 결합: unconjugated
• application: FACS; ICC; WB
• 클론: polyclonal
• 종 반응성: human
• citations: 3
• 기술: flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells (per 10⁶ cells); immunocytochemistry: 1:25; western blot: 1:200 using HEK-K_V11.1 transfected cells

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: lyophilized powder
• 종 반응성: human
• 기술: flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells (per 10⁶ cells); immunocytochemistry: 1:25; western blot: 1:200 using HEK-K_V11.1 transfected cells
• UniProt 수납 번호: Q12809
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... KCNH2(3757) ; mouse ... Kcnh2(16511) ; rat ... Kcnh2(117018)

설명

일반 설명

The K⁺ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K⁺ channels based on the number of transmembrane domains. The voltage-gated Potassium or K_v channels belong to the 6 TM K⁺ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. K_v11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in K_v11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. K_v11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel K_v11.1 extracellular antibodies are specific to K_v11.1.

면역원

peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human K_V11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.

애플리케이션

Anti-Potassium channel K_v11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of K_v11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.

물리적 형태

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable