추천 제품
제품명
Monoclonal Anti-Parvalbumin antibody produced in mouse, clone PARV-19, ascites fluid
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
ascites fluid
항체 생산 유형
primary antibodies
클론
PARV-19, monoclonal
분자량
antigen 12 kDa
포함
15 mM sodium azide
종 반응성
fish, frog, rabbit, canine, feline, bovine, pig, human, goat, rat
기술
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable (10-20K titer using Mouse skeletal muscle extract expressing Parvalbumin protein)
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... PVALB(5816)
rat ... Pvalb(25269)
일반 설명
PVALB (parvalbumin) is a classical small member of the low molecular weight, acidic protein family known as calcium binding proteins (CaBPs) EF-hand superfamily. This protein shows a restricted pattern of expression in brain and muscle. It is a cytoplasmic high affinity CaBP.
Monoclonal Anti-Parvalbumin (mouse IgG1 isotype) is derived from the PARV-19 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Parvalbumin is a calcium-binding protein.
Monoclonal Anti-Parvalbumin (mouse IgG1 isotype) is derived from the PARV-19 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Parvalbumin is a calcium-binding protein.
특이성
Recognizes parvalbumin in a Ca2+ ion-dependent manner. Does not react with other members of the EF-hand family such as calmodulin, intestinal calcium-binding protein, S100A2 (S100L), S100A6 (calcyclin), the α chain of S-100 (i.e. in S-100a and S-100ao), or the β chain (i.e. in S-100a and S-100b).
면역원
Frog muscle parvalbumin.
애플리케이션
Monoclonal Anti-Parvalbumin antibody produced in mouse has been used for immunohistochemistry, immunocytochemistry, and immunofluorescence.
생화학적/생리학적 작용
PVALB (parvalbumin) protein modulates relaxation in fast contracting muscles, where it localizes to type II (fast-twitch) mammalian skeletal muscle fibres in small mammals. This protein is a crucial regulator of neuronal intracellular calcium dynamics. PVALB protein maintains synaptic transmission during bursts, where it prevents presynaptic Ca2+ accumulation and hence the harmful effects of excess presynaptic Ca2+ levels. It also maintains synaptic transmission by allowing for linear information processing post-synaptically by preventing cumulative neuronal facilitation.
PVALB (parvalbumin) expression serves as marker for differentiating tumors as benign and malignant, in relation with thyroid lesions. Decreased expression of parvalbumin positive interneurons in rat model is associated with schizophrenia, and is known to disturb neuronal activity.
PVALB (parvalbumin) expression serves as marker for differentiating tumors as benign and malignant, in relation with thyroid lesions. Decreased expression of parvalbumin positive interneurons in rat model is associated with schizophrenia, and is known to disturb neuronal activity.
물리적 형태
Liquid
저장 및 안정성
For continuous use, store at 2-8 °C for up to one month.
For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Dynamics of parvalbumin expression in low-frequency-stimulated fast-twitch rat muscle.
Huber B and Pette D
European Journal of Biochemistry, 236(3), 814-819 (1996)
Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: partial colocalization with mature interneuron markers.
Xiong K, et al.
Experimental Neurology, 211(1), 271-282 (2008)
Calcium-binding protein parvalbumin as a neuronal marker.
Celio MR and Heizmann CW
Nature, 293(5830), 300-302 (1981)
Nobutake Hosoi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(32), 6339-6353 (2019-06-16)
ADP-ribosylation factors (ARFs) are a family of small monomeric GTPases comprising six members categorized into three classes: class I (ARF1, 2, and 3), class II (ARF4 and 5), and class III (ARF6). In contrast to class I and III ARFs
Parvalbumin in most gamma-aminobutyric acid-containing neurons of the rat cerebral cortex.
Celio MR
Science, 231(4741), 995-997 (1986)
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