추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
predicted mol wt 54 kDa
종 반응성
mouse, human
기술
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... STEAP2(261729)
관련 카테고리
일반 설명
The Six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a metalloreductase that belongs to the STEAP family. It is localized in secretory and endocytic pathway organelles. The STEAP2 gene is mapped to human chromosome 7q21.13.
면역원
a 16 amino acid peptide from near the carboxy-terminus of human STEAP2.
생화학적/생리학적 작용
The Six-transmembrane epithelial antigen of prostate 2 (STEAP2) being localized in Golgi membrane and cytoplasmic vesicles, may have a critical role in the endocytic pathway. It is highly expressed in prostate carcinomas (PCa) and promotes tumor invasion and migration. Along with STEAP3 and 4, STEAP2 levels are implicated in favoring copper and iron uptake. Studies on targeted STEAP2 knockdown have reported a reduction in PCa progression.
결합
The action of this antibody can be blocked using blocking peptide SBP4307.
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Stephanie E A Burnell et al.
Scientific reports, 8(1), 6252-6252 (2018-04-21)
Six-transmembrane epithelial antigen of the prostate-2 (STEAP2) expression is increased in prostate cancer when compared to normal prostate, suggesting STEAP2 may drive prostate cancer progression. This study aimed to establish the functional role of STEAP2 in prostate tumourigenesis and evaluate
Shadia M Ihlaseh-Catalano et al.
Histopathology, 63(5), 678-685 (2013-09-13)
To investigate the prognostic value of expression levels of the genes STEAP1 and STEAP2, and of STEAP1 protein, in prostate carcinomas (PCa). STEAP1 and STEAP2 transcript levels were evaluated by RT-qPCR in samples from 35 PCa, 24 adjacent non-neoplastic prostate
Haruki Hasegawa et al.
Experimental cell research, 370(2), 208-226 (2018-06-26)
STEAP2 is a member of the Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) protein family that is proposed to function as metalloreductase. While STEAP2 shows a complex subcellular distribution pattern localizing to both secretory and endocytic pathway organelles, how such
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