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Merck
모든 사진(1)

문서

R0283

Sigma-Aldrich

Ropivacaine hydrochloride monohydrate

≥98% (HPLC)

동의어(들):

(2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate, (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate, Naropin hydrochloride monohydrate

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About This Item

실험식(Hill 표기법):
C17H26N2O · HCl · H2O
CAS Number:
Molecular Weight:
328.88
MDL number:
UNSPSC 코드:
12352203
PubChem Substance ID:
NACRES:
NA.77

Quality Level

분석

≥98% (HPLC)

형태

powder

광학 활성

[α]/D -9 to -12, c = 1 in methanol

저장 조건

desiccated

색상

white to off-white

solubility

H2O: 5 mg/mL, clear

주관자

AstraZeneca

저장 온도

2-8°C

SMILES string

O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C

InChI

1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1

InChI key

VSHFRHVKMYGBJL-CKUXDGONSA-N

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일반 설명

Ropivacaine has lidocaine-related structure with tertiary amine side chains. It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.

애플리케이션

Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

생화학적/생리학적 작용

Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.
Ropivacaine less lipophilic as compared with bupivacaine. It is metabolized in the liver by the enzyme cytochrome P4501A2. Ropivacaine elicits less central nervous system (CNS) toxicity and is used as a local anaesthetic during postoperative and labour pain.

특징 및 장점

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Corrosion

신호어

Danger

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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