R4033
Rosmarinic acid
≥98% (HPLC), from Rosemarinus officinalis L.
동의어(들):
(R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid, 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester
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모든 사진(3)
About This Item
실험식(Hill 표기법):
C18H16O8
CAS Number:
Molecular Weight:
360.31
Beilstein:
2227587
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.25
추천 제품
생물학적 소스
Rosemarinus officinalis L.
Quality Level
분석
≥98% (HPLC)
양식
powder
저장 조건
protect from light
색상
white to faint beige
mp
171-175 °C (lit.)
solubility
H2O: 1 mg/mL, clear, colorless
응용 분야
metabolomics
vitamins, nutraceuticals, and natural products
저장 온도
2-8°C
SMILES string
OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2
InChI
1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
InChI key
DOUMFZQKYFQNTF-WUTVXBCWSA-N
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일반 설명
Rosmarinic acid is a naturally occurring polyphenolic compound found in plants of the Boraginaceae family and Nepetoideae subfamily. It is an ester of caffeic acid as well as 3,4-dihydroxy-phenyllactic acid.
애플리케이션
Rosmarinic acid has been used:
- to see its protective effects on the human endothelial cell line (EA.hy926) to treat diabetic atherosclerosis
- to test its effect in 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced Parkinson′s disease (PD) models on attenuating inflammatory responses and microglia activation
- to test its neuroprotective effects on dopaminergic neurons
- to test its effects on sperm motility, viability and on intracellular calcium ion concentration
- as a reference standard in capillary zone electrophoresis (CZE) method
생화학적/생리학적 작용
Rosmarinic acid (RosA) is a well-appreciated agent used in several diabetic conditions and complications such as diabetic nephropathy, diabetic neuropathy and diabetic atherosclerosis. It has also been implicated to be a neuroprotective agent for several neurological disorders such as Alzheimer′s disease, Parkinson′s disease, and epilepsy by suppressing their conditions.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
Polyphenols analysis from different medicinal plants extracts using capillary zone electrophoresis (CZE)
Matei AO, et al.,
Revista de Chimie, 67, 1051-1105 (2016)
Meng-Ge Lv et al.
Reproductive toxicology (Elmsford, N.Y.), 81, 58-63 (2018-07-17)
Rosmarinic acid (RA), a natural phenolic ester, is cytoprotective for male reproduction in animal models. The present study investigated the in vitro actions of RA on human sperm functions. Human sperm were exposed to 1, 10, 100, and 1000 μM
A Oğuz et al.
Folia morphologica, 79(2), 288-295 (2019-08-23)
The aim of the study was to investigate the protective effects of rosmarinic acid in rats exposed to hepatic ischaemia/reperfusion (I/R) injury. Thirty-two rats were randomly classified into four groups of 8 rats each: laparotomy without medication, rosmarinic acid (dose
Tomoki Hase et al.
Scientific reports, 9(1), 8711-8711 (2019-06-20)
A new mechanism is revealed by which a polyphenol, rosmarinic acid (RA), suppresses amyloid β (Aβ) accumulation in mice. Here we examined the brains of mice (Alzheimer's disease model) using DNA microarray analysis and revealed that the dopamine (DA)-signaling pathway
Cristina Airoldi et al.
Chemistry, an Asian journal, 8(3), 596-602 (2013-01-11)
Amyloid peptides, Aβ1-40 and Aβ1-42, represent major molecular targets to develop potential drugs and diagnostic tools for Alzheimer's Disease (AD). In fact, oligomeric and fibrillar aggregates generated by these peptides are amongst the principal components of amyloid plaques found post
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