추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
purified from hybridoma cell culture
항체 생산 유형
primary antibodies
클론
12F5, monoclonal
분자량
antigen ~25 kDa
종 반응성
human, mouse, canine
기술
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 0.5-1 μg/mL using HeLa nuclear cell extract
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... SNRPB(6628)
mouse ... Snrpb(20638)
일반 설명
Monoclonal Anti-SmB (mouse IgG1 isotype) is derived from the hybridoma 12F5-H3.D8 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with an SmB recombinant protein.
SNRPB (small nuclear ribonucleoprotein-associated protein B) is an important constituent of the spliceosome. It codes for SmB/B′ (small nuclear ribonucleoprotein polypeptides B and B1). It is located on human chromosome 20p13. SmB′/B are upregulated in all tissues excluding postnatal brain.
면역원
SmB recombinant protein.
애플리케이션
- Monoclonal Anti-SmB antibody produced in mouse has been used in:
- western blotting
- enzyme-linked immunosorbent assay (ELISA)
- immunoprecipitation
- immunocytochemistry
생화학적/생리학적 작용
SNRPB (small nuclear ribonucleoprotein-associated protein B) mutations results in cerebro-costo-mandibular syndrome. Downregulation of SNRPB affects the upregulation and processing of RNA splicing machinery components. It also plays a major role in RNA stability.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma
Correa BR, et al.
Genome Biology, 17(1) (2016)
Smed-SmB, a member of the LSm protein superfamily, is essential for chromatoid body organization and planarian stem cell proliferation
Fernandez-TE, et al.
Development, 137(7), 1055-1065 (2010)
Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci
Gray TA, et al.
Nucleic Acids Research, 27(23), 4577-4584 (1999)
U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein
Skrajna A, et al.
RNA, 23(6), 938-951 (2017)
CARM1 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis
Greenblatt SM, et al.
Cancer Cell, 33, 1111-1127 (2018)
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