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Merck
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Key Documents

S9442

Sigma-Aldrich

Anti-Synaptopodin (SE-19) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

IgG fraction of antiserum

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 100 kDa

종 반응성

rat

기술

microarray: suitable
western blot: 1:3,000 using cytosolic S1 fraction of rat brain

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... SYNPO(11346)
rat ... Synpo(60324)

관련 카테고리

일반 설명

Synaptopodin is a proline-rich, actin-associated protein (100 kDa) is present in the post-synaptic density (PSD) in actin cytoskeleton. It is also present in the dendritic spines and differentiated podocytes. Synaptopodin contains a high amount of proline residues (~20%), which are evenly distributed along the protein sequence, thus virtually excluding the formation of globular domains. In particular, synaptopodin does not contain functional domains found in receptor clustering PSD proteins. Sequence comparison between human and mouse synaptopodin shows 84% identity. The exclusive site of synaptopodin expression in the telencephalon is restricted to specific areas of high synaptic plasticity, i.e. in the perykaria of the olfactory bulb, striatum, and hippocampus.

면역원

synthetic peptide corresponding to amino acids 184-202 of rat synaptopodin conjugated to KLH. This rat synaptopodin sequence has ~70% identity with human synaptopodin.

애플리케이션

Anti-Synaptopodin (SE-19) antibody produced in rabbit has been used in:
  • immunofluorescence microscopy
  • immunohistochemistry
  • western blotting

생화학적/생리학적 작용

Synaptopodin is thought to play an important role in synaptic plasticity and is associated in the modulation of motility of actin in neuronal dendritic spines. The association of synaptopodin with the specialized actin system of renal podocyte foot processes suggests that it may play a role in actin cytoskeleton dynamics of these cellular extensions. Synaptopodin has been found to interact with α-actinin-4 and the tight junction protein Membrane-associated guanylate kinase inverted 1 (MAGI-1) in Madin-Darby Canine Kidney (MDCK) cells.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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픽토그램

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신호어

Warning

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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