추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen ~21 kDa
종 반응성
human
기술
western blot: 1:500-1:2,000
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... RNF4(6047)
일반 설명
Really interesting new gene (RING ) finger protein 4 (RNF4) gene encodes ubiquitin E3 ligase, an enzyme widely expressed in many tissues. The protein contains a RING (really interesting new gene) finger domain and around three small ubiquitin-related modifier (SUMO)-interaction motifs. RNF4 is mapped to human chromosome 4p16.3.
면역원
synthetic peptide corresponding to amino acids 176-190 of human RNF4
애플리케이션
Anti-RNF4 (176-190) antibody produced in rabbit has been used in western blotting analysis.
생화학적/생리학적 작용
Really interesting new gene (RING ) finger protein 4 (RNF4) catalyzes the ubiquitylation of proteins associated with small ubiquitin-related modifier (SUMO). Rnf4 is involved in DNA repair, in transcription and chromatin regulation. It is also associated with the process of hematopoiesis. RNF4 is implicated in acute promyelocytic leukemia, acute myeloid leukemia, Fanconi anemia and aplastic anemia.
표적 설명
RNF4 (176-190), ring finger protein 4. encodes a protein that contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
E1B-55K-mediated regulation of RNF4 SUMO-targeted ubiquitin ligase promotes human adenovirus gene expression
Muncheberg S, et al.
Journal of Virology, 92(13), e00164-e00118 (2018)
RNF4 regulates zebrafish granulopoiesis through the DNMT1-C/EBPalpha axis
Wang L, et al.
Faseb Journal, 32(9), 4930-4940 (2018)
RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors
Pero R, et al.
The American Journal of Pathology, 159(4), 1225-1230 (2001)
HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
Wang WF, et al.
Nature Communications, 8(1), 363-363 (2017)
Wen-Fang Wang et al.
Nature communications, 8(1), 363-363 (2017-08-27)
B lymphocyte-induced maturation protein-1 (Blimp-1) ensures B-cell differentiation into the plasma cell stage, and its instability constitutes a crucial oncogenic element in certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL). However, the underlying degradation mechanisms and
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