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Merck
모든 사진(3)

주요 문서

SAB2500963

Sigma-Aldrich

Anti-Smooth Muscle α-Actin antibody produced in goat

affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-ACTA2, Anti-OTTHUMP00000020042

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

goat

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

종 반응성

human, mouse, rat

기술

ELISA: suitable
western blot: suitable

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ACTA2(59)

일반 설명

Actin, a highly conserved protein, is a major component of both the cytoskeletal and contractile structures in all cell types. It varies in amount related to the type of differentiation and to the functional state of cells and tissues. Actin can be found in two different forms of aggregation, the globular or the fibrillar state, and at least six distinct isoforms occur in vertebrates. The actins exhibit over 90% sequence homology, but each isoform has a unique NH2-terminal sequence. The isoforms are comprised of three α actins (skeletal, cardiac, smooth), one β actin (β-non-muscle) and two γ actins (γ smooth muscle and γ non-muscle). Difficulties have been encountered in producing polyclonal antibodies due to the highly conserved nature of actin.
Goat polyclonal anti-smooth muscle α-Actin antibody reacts with canine, human, mouse, and rat smooth muscle α-actins (ACTA2).

면역원

Peptide with sequence EEEDSTALVC from the N Terminus of the protein sequence according to NP_001604.1.

애플리케이션

Goat polyclonal anti-smooth muscle α-Actin antibody is used to tag smooth muscle α-actin (ACTA2) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of smooth muscle α-actin in smooth muscle structure and as a marker of myofibroblast formation.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Riccardo Coletta et al.
Journal of tissue engineering and regenerative medicine, 10(2), 178-182 (2015-08-04)
The ability to grow embryonic organs ex vivo provides an opportunity to follow their differentiation in a controlled environment, with resulting insights into normal development. Additionally, similar strategies can be used to assess effects on organogenesis of physical and chemical
Rebecca M Shaffer et al.
American journal of obstetrics and gynecology, 221(4), 330-330 (2019-05-19)
The use of polypropylene prolapse mesh to treat pelvic organ prolapse has been limited by mesh-related complications. Gynemesh PS mesh, implanted via sacrocolpopexy in rhesus macaques, had a negative impact on the vagina with thinning of vaginal muscularis and decreased
Mitchell R Ladd et al.
Tissue engineering. Part C, Methods, 24(6), 331-345 (2018-04-12)
Short bowel syndrome (SBS) is a major cause of morbidity and mortality in the pediatric population, for which treatment options are limited. To develop novel approaches for the treatment of SBS, we now focus on the development of a tissue-engineered
Maha Abdalla et al.
The Journal of biological chemistry, 288(46), 33483-33493 (2013-10-10)
Myofibroblast (MF) differentiation, marked by the de novo expression of smooth muscle α-actin (αSMA) stress fibers, plays a central role in wound healing and its persistence is a hallmark of fibrotic diseases. We have previously shown that Akt1 is necessary
Seol-Hee Kim et al.
eNeuro, 9(2) (2022-04-03)
The airways are densely innervated by sensory afferent nerves, whose activation regulates respiration and triggers defensive reflexes (e.g., cough, bronchospasm). Airway innervation is heterogeneous, and distinct afferent subsets have distinct functional responses. However, little is known of the innervation patterns

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